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- W2136255280 abstract "Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity. In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not associated with clinicopathologic features of angiogenesis such as VEGF activity and the micro-vessel density and survival of breast cancer patients. Taken together, the 1772 C > T of HIF-1α gene is a potential biomarker for breast cancer susceptibility." @default.
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- W2136255280 date "2014-09-26" @default.
- W2136255280 modified "2023-10-16" @default.
- W2136255280 title "SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population" @default.
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- W2136255280 doi "https://doi.org/10.1186/s12935-014-0087-7" @default.
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- W2136255280 hasPublicationYear "2014" @default.
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