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• W2136259733 startingPage "1645" @default.
• W2136259733 abstract "“Lipid rafts” enriched in glycosphingolipids (GSL), GPI-anchored proteins, and cholesterol have been proposed as functional microdomains in cell membranes. However, evidence supporting their existence has been indirect and controversial. In the past year, two studies used fluorescence resonance energy transfer (FRET) microscopy to probe for the presence of lipid rafts; rafts here would be defined as membrane domains containing clustered GPI-anchored proteins at the cell surface. The results of these studies, each based on a single protein, gave conflicting views of rafts. To address the source of this discrepancy, we have now used FRET to study three different GPI-anchored proteins and a GSL endogenous to several different cell types. FRET was detected between molecules of the GSL GM1 labeled with cholera toxin B-subunit and between antibody-labeled GPI-anchored proteins, showing these raft markers are in submicrometer proximity in the plasma membrane. However, in most cases FRET correlated with the surface density of the lipid raft marker, a result inconsistent with significant clustering in microdomains. We conclude that in the plasma membrane, lipid rafts either exist only as transiently stabilized structures or, if stable, comprise at most a minor fraction of the cell surface." @default.
• W2136259733 created "2016-06-24" @default.
• W2136259733 creator A5012850937 @default.
• W2136259733 creator A5041313807 @default.
• W2136259733 creator A5043123302 @default.
• W2136259733 date "2000-05-01" @default.
• W2136259733 modified "2023-10-09" @default.
• W2136259733 title "High-Resolution FRET Microscopy of Cholera Toxin B-Subunit and GPI-anchored Proteins in Cell Plasma Membranes" @default.
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• W2136259733 doi "https://doi.org/10.1091/mbc.11.5.1645" @default.
• W2136259733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/14873" @default.
• W2136259733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10793141" @default.
• W2136259733 hasPublicationYear "2000" @default.
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