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• W2136267260 abstract "Abstract The reactions of hydrated electrons (e aq − ) with 8‐bromo‐2′‐deoxyinosine ( 8 ) and 8‐bromoinosine ( 12 ) have been investigated by radiolytic methods coupled with product studies and have been addressed computationally by means of BB1K‐HMDFT calculations. Pulse radiolysis revealed that one‐electron reductive cleavage of the CBr bond gives the C8 radical 9 or 13 followed by a fast radical translocation to the sugar moiety. Selective generation of a C5′ radical occurs in the 2′‐deoxyribo derivative, whereas in the ribo analogue the reaction is partitioned between the C5′ and C2′ positions with similar rates. Both C5′ radicals undergo cyclizations, 10 → 11 and 14 → 15 , with rate constants of 1.4×10 5 and of 1.3×10 4 s −1 , respectively. The redox properties of radicals 10 and 11 have also been investigated. A synthetically useful photoreaction has also been developed as a one‐pot procedure that allows the conversion of 8 to 5′,8‐cyclo‐2′‐deoxyinosine in a high yield and a diastereoisomeric ratio (5′ R )/(5′ S ) of 4:1. The present results are compared with data previously obtained for 8‐bromoadenine and 8‐bromoguanine nucleosides. Theory suggests that the behavior of 8‐bromopurine derivatives with respect to solvated electrons can be attributed to differences in the energy gap between the π*‐ and σ*‐radical anions." @default.
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• W2136267260 date "2006-09-28" @default.
• W2136267260 modified "2023-10-17" @default.
• W2136267260 title "Chemical Radiation Studies of 8-Bromo-2′-deoxyinosine and 8-Bromoinosine in Aqueous Solutions" @default.
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• W2136267260 doi "https://doi.org/10.1002/chem.200600040" @default.
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