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- W2136271967 abstract "unclear how dietary factors including increased fat intake may alter the composition of cellular membranes (both host and bacterial) and stool phospholipid profiles in both health and disease. Thus, we aimed to examine the lipid profile and microbial communities of stool samples from mice fed a control (10% calories from fat) or a high fat diet (HFD: 60% calories from fat) and after induction of colitis-associated tumors by AOM-DSS treatment. Phospholipids from stool were extracted and four classes of phospholipids were analyzed by triple quadrupole electrospray mass spectrometry (phosphotidylcholine, phosphotidylinositol, phosphotidylethanolamine, and phosphotidylserine). Peak masses were detected using MZmine 2.9 software and phospholipids identified using LipidMaps database. Microbiota was analyzed by automated ribosomal intergenic spacer analysis (ARISA) and qPCR for representative bacterial groups. Feeding a HFD did not significantly alter the total quantities of the phospholipids analyzed. However, tumor-bearing mice fed a control diet had significantly decreased total phosphotidylinositols compared to healthy control diet counterparts. Analysis of quantities of individual species of phospholipids revealed the greatest number of differences due to the presence of tumors rather than differences in diet as determined by partial-least squares discriminant analysis (PLS-DA) plotting. Our microbial analysis was consistent with previous studies in that we observed decreased quantities of Bacteroidetes and increased Firmicutes in animals fed a HFD. When we examined the presence or absence of identified microbial populations both diet and the presence of tumors were found to separate groups using principal component analysis (PCA). Consistent with the observation that phospholipid species were the most different between healthy and tumor bearing mice, the microbial communities also had the greatest variation based on this separation. Thus, we show that feeding a HFD and the presence of colitis-associated tumors alters both the stool phospholipid profile and the microbiota. Profiling the lipidome and the microbiome of stool in different dietary states will be an important area for future nutritional studies and may provide novel biomarkers to assess the health of both the host and its microbiota." @default.
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- W2136271967 date "2014-05-01" @default.
- W2136271967 modified "2023-09-26" @default.
- W2136271967 title "805 Computer-Aided Detection of Early Neoplastic Lesions in Barrett's Esophagus: Towards a Supportive Detection System in Endoscopy" @default.
- W2136271967 doi "https://doi.org/10.1016/s0016-5085(14)60499-6" @default.
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