FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136276388> ?p ?o ?g. }

• W2136276388 endingPage "1485" @default.
• W2136276388 startingPage "1476" @default.
• W2136276388 abstract "The purpose of this study was to examine the role of tumor necrosis factor receptor 1 (TNFR1) in the airway hyperresponsiveness characteristic of obese mice. Airway responsiveness to intravenous methacholine was measured using the forced oscillation technique in obese Cpe fat mice that were either sufficient or genetically deficient in TNFR1 ( Cpe fat and Cpe fat /TNFR1 −/− mice) and in lean mice that were either sufficient or genetically deficient in TNFR1 [wild-type (WT) and TNFR1 −/− mice]. Compared with lean WT mice, Cpe fat mice exhibited airway hyperresponsiveness. Airway hyperresponsives was also greater in Cpe fat /TNFR1 −/− than in Cpe fat mice. Compared with WT mice, Cpe fat mice had increases in bronchoalveolar lavage fluid concentrations of several inflammatory moieties including eotaxin, IL-9, IP-10, KC, MIG, and VEGF. These factors were also significantly elevated in Cpe fat /TNFR1 −/− vs. TNFR1 −/− mice. Additional moieties including IL-13 were also elevated in Cpe fat /TNFR1 −/− vs. TNFR1 −/− mice but not in Cpe fat vs. WT mice. IL-17A mRNA expression was greater in Cpe fat /TNFR1 −/− vs. Cpe fat mice and in TNFR1 −/− vs. WT mice. Analysis of serum indicated that obesity resulted in systemic as well as pulmonary inflammation, but TNFR1 deficiency had little effect on this systemic inflammation. Our results indicate that TNFR1 is protective against the airway hyperresponsiveness associated with obesity and suggest that effects on pulmonary inflammation may be contributing to this protection." @default.
• W2136276388 created "2016-06-24" @default.
• W2136276388 creator A5000963485 @default.
• W2136276388 creator A5035260139 @default.
• W2136276388 creator A5039574700 @default.
• W2136276388 creator A5049845466 @default.
• W2136276388 creator A5054413291 @default.
• W2136276388 creator A5068560690 @default.
• W2136276388 date "2012-11-01" @default.
• W2136276388 modified "2023-10-18" @default.
• W2136276388 title "Role of TNFR1 in the innate airway hyperresponsiveness of obese mice" @default.
• W2136276388 cites W1488883333 @default.
• W2136276388 cites W1530909461 @default.
• W2136276388 cites W1586543272 @default.
• W2136276388 cites W1764140709 @default.
• W2136276388 cites W1964899306 @default.
• W2136276388 cites W1964924481 @default.
• W2136276388 cites W1966875787 @default.
• W2136276388 cites W1967567207 @default.
• W2136276388 cites W1970777915 @default.
• W2136276388 cites W1971614601 @default.
• W2136276388 cites W1973228855 @default.
• W2136276388 cites W1976373666 @default.
• W2136276388 cites W1984113136 @default.
• W2136276388 cites W1988109900 @default.
• W2136276388 cites W1993901681 @default.
• W2136276388 cites W1994010844 @default.
• W2136276388 cites W1994457502 @default.
• W2136276388 cites W1994479791 @default.
• W2136276388 cites W1995377908 @default.
• W2136276388 cites W1998962160 @default.
• W2136276388 cites W1999603992 @default.
• W2136276388 cites W2001920370 @default.
• W2136276388 cites W2004333290 @default.
• W2136276388 cites W2008041676 @default.
• W2136276388 cites W2009788528 @default.
• W2136276388 cites W2010067104 @default.
• W2136276388 cites W2012487047 @default.
• W2136276388 cites W2013394968 @default.
• W2136276388 cites W2016395601 @default.
• W2136276388 cites W2016979581 @default.
• W2136276388 cites W2023878183 @default.
• W2136276388 cites W2032064406 @default.
• W2136276388 cites W2035239105 @default.
• W2136276388 cites W2036625848 @default.
• W2136276388 cites W2038217946 @default.
• W2136276388 cites W2038545995 @default.
• W2136276388 cites W2051200995 @default.
• W2136276388 cites W2059652342 @default.
• W2136276388 cites W2064954598 @default.
• W2136276388 cites W2069681479 @default.
• W2136276388 cites W2071073097 @default.
• W2136276388 cites W2072353509 @default.
• W2136276388 cites W2077017142 @default.
• W2136276388 cites W2080998956 @default.
• W2136276388 cites W2086121828 @default.
• W2136276388 cites W2086648828 @default.
• W2136276388 cites W2093741356 @default.
• W2136276388 cites W2098511054 @default.
• W2136276388 cites W2104666007 @default.
• W2136276388 cites W2105078806 @default.
• W2136276388 cites W2107277218 @default.
• W2136276388 cites W2107389329 @default.
• W2136276388 cites W2107680108 @default.
• W2136276388 cites W2110749444 @default.
• W2136276388 cites W2111888923 @default.
• W2136276388 cites W2112511234 @default.
• W2136276388 cites W2118443170 @default.
• W2136276388 cites W2120282627 @default.
• W2136276388 cites W2120317645 @default.
• W2136276388 cites W2120480222 @default.
• W2136276388 cites W2121161301 @default.
• W2136276388 cites W2123895022 @default.
• W2136276388 cites W2124566107 @default.
• W2136276388 cites W2130064617 @default.
• W2136276388 cites W2135567354 @default.
• W2136276388 cites W2136172944 @default.
• W2136276388 cites W2137536467 @default.
• W2136276388 cites W2140602955 @default.
• W2136276388 cites W2147587800 @default.
• W2136276388 cites W2149573313 @default.
• W2136276388 cites W2150275143 @default.
• W2136276388 cites W2152764690 @default.
• W2136276388 cites W2153191296 @default.
• W2136276388 cites W2153798846 @default.
• W2136276388 cites W2160103886 @default.
• W2136276388 cites W2160309307 @default.
• W2136276388 cites W2160977408 @default.
• W2136276388 cites W2161146254 @default.
• W2136276388 cites W2161950337 @default.
• W2136276388 cites W2163652669 @default.
• W2136276388 cites W2166428721 @default.
• W2136276388 cites W2167124184 @default.
• W2136276388 cites W2168248213 @default.
• W2136276388 cites W2169449937 @default.
• W2136276388 cites W2169930621 @default.
• W2136276388 cites W4249727000 @default.
• W2136276388 doi "https://doi.org/10.1152/japplphysiol.00588.2012" @default.

• next