FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136285655> ?p ?o ?g. }

• W2136285655 endingPage "5144" @default.
• W2136285655 startingPage "5137" @default.
• W2136285655 abstract "Abstract Purpose: The molecular mechanisms underlying lymph node metastasis are poorly understood, despite the well-established clinical importance of lymph node status in many human cancers. Recently, vascular endothelial growth factor (VEGF)-C and VEGF-D have been implicated in the regulation of tumor lymphangiogenesis and enhancement of lymphatic invasion via activation of VEGF receptor-3. The purpose of this study was to determine the expression pattern of the VEGF-C/VEGF-D/VEGF receptor-3 axis in prostate cancer and its relationship with lymph node metastasis. Experimental Design: The expression pattern of VEGF-C, VEGF-D, and VEGF receptor-3 in localized prostate cancer specimens (n = 37) was determined using immunohistochemistry. Results: Widespread, heterogeneous staining for VEGF-C and VEGF-D was observed in all cancer specimens. Intensity of VEGF-C staining was lower in benign prostate epithelium than in adjacent carcinoma, whereas no difference between benign epithelium and carcinoma was observed for VEGF-D staining. VEGF receptor-3 immunostaining was detected in endothelial cells of lymphatic vessels in 18 of 37 tissue samples. The presence of VEGF receptor-3-positive vessels was associated with lymph node metastasis (P = 0.0002), Gleason grade (P &lt; 0.0001), extracapsular extension (P = 0.0382), and surgical margin status (P = 0.0069). In addition, VEGF receptor-3 staining highlighted lymphatic invasion by VEGF-C-positive/VEGF-D-positive carcinoma cells. Conclusions: Together, these results suggest that paracrine activation of lymphatic endothelial cell VEGF receptor-3 by VEGF-C and/or VEGF-D may be involved in lymphatic metastasis. Thus the VEGF-C/VEGF-D/VEGF receptor-3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer." @default.
• W2136285655 created "2016-06-24" @default.
• W2136285655 creator A5027248689 @default.
• W2136285655 creator A5027343203 @default.
• W2136285655 creator A5032077313 @default.
• W2136285655 creator A5037559513 @default.
• W2136285655 creator A5052143564 @default.
• W2136285655 creator A5084855225 @default.
• W2136285655 creator A5086873007 @default.
• W2136285655 creator A5089835242 @default.
• W2136285655 date "2004-08-01" @default.
• W2136285655 modified "2023-09-23" @default.
• W2136285655 title "Expression of Vascular Endothelial Growth Factor Receptor-3 by Lymphatic Endothelial Cells Is Associated with Lymph Node Metastasis in Prostate Cancer" @default.
• W2136285655 cites W1489873347 @default.
• W2136285655 cites W1520425169 @default.
• W2136285655 cites W1570971207 @default.
• W2136285655 cites W1649424423 @default.
• W2136285655 cites W1965423355 @default.
• W2136285655 cites W1966036978 @default.
• W2136285655 cites W1970616812 @default.
• W2136285655 cites W1974097718 @default.
• W2136285655 cites W1978874249 @default.
• W2136285655 cites W1979807471 @default.
• W2136285655 cites W1995658890 @default.
• W2136285655 cites W2008691375 @default.
• W2136285655 cites W2012852444 @default.
• W2136285655 cites W2025173623 @default.
• W2136285655 cites W2025933554 @default.
• W2136285655 cites W2026642794 @default.
• W2136285655 cites W2027981903 @default.
• W2136285655 cites W2049582178 @default.
• W2136285655 cites W2051421411 @default.
• W2136285655 cites W2055069711 @default.
• W2136285655 cites W2073704598 @default.
• W2136285655 cites W2118282739 @default.
• W2136285655 cites W2120271422 @default.
• W2136285655 cites W2159241628 @default.
• W2136285655 cites W2160579552 @default.
• W2136285655 cites W2160621761 @default.
• W2136285655 cites W2164738538 @default.
• W2136285655 cites W2171543828 @default.
• W2136285655 cites W2475324104 @default.
• W2136285655 cites W4248332364 @default.
• W2136285655 doi "https://doi.org/10.1158/1078-0432.ccr-03-0434" @default.
• W2136285655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15297417" @default.
• W2136285655 hasPublicationYear "2004" @default.
• W2136285655 type Work @default.
• W2136285655 sameAs 2136285655 @default.
• W2136285655 citedByCount "96" @default.
• W2136285655 countsByYear W21362856552012 @default.
• W2136285655 countsByYear W21362856552013 @default.
• W2136285655 countsByYear W21362856552014 @default.
• W2136285655 countsByYear W21362856552016 @default.
• W2136285655 countsByYear W21362856552017 @default.
• W2136285655 countsByYear W21362856552018 @default.
• W2136285655 countsByYear W21362856552019 @default.
• W2136285655 countsByYear W21362856552021 @default.
• W2136285655 crossrefType "journal-article" @default.
• W2136285655 hasAuthorship W2136285655A5027248689 @default.
• W2136285655 hasAuthorship W2136285655A5027343203 @default.
• W2136285655 hasAuthorship W2136285655A5032077313 @default.
• W2136285655 hasAuthorship W2136285655A5037559513 @default.
• W2136285655 hasAuthorship W2136285655A5052143564 @default.
• W2136285655 hasAuthorship W2136285655A5084855225 @default.
• W2136285655 hasAuthorship W2136285655A5086873007 @default.
• W2136285655 hasAuthorship W2136285655A5089835242 @default.
• W2136285655 hasConcept C103041312 @default.
• W2136285655 hasConcept C121608353 @default.
• W2136285655 hasConcept C126322002 @default.
• W2136285655 hasConcept C142724271 @default.
• W2136285655 hasConcept C146285616 @default.
• W2136285655 hasConcept C167734588 @default.
• W2136285655 hasConcept C181152851 @default.
• W2136285655 hasConcept C2776636583 @default.
• W2136285655 hasConcept C2777025900 @default.
• W2136285655 hasConcept C2778740770 @default.
• W2136285655 hasConcept C2779013556 @default.
• W2136285655 hasConcept C2780192828 @default.
• W2136285655 hasConcept C2780849966 @default.
• W2136285655 hasConcept C2780965494 @default.
• W2136285655 hasConcept C2910366181 @default.
• W2136285655 hasConcept C502942594 @default.
• W2136285655 hasConcept C71924100 @default.
• W2136285655 hasConcept C86803240 @default.
• W2136285655 hasConceptScore W2136285655C103041312 @default.
• W2136285655 hasConceptScore W2136285655C121608353 @default.
• W2136285655 hasConceptScore W2136285655C126322002 @default.
• W2136285655 hasConceptScore W2136285655C142724271 @default.
• W2136285655 hasConceptScore W2136285655C146285616 @default.
• W2136285655 hasConceptScore W2136285655C167734588 @default.
• W2136285655 hasConceptScore W2136285655C181152851 @default.
• W2136285655 hasConceptScore W2136285655C2776636583 @default.
• W2136285655 hasConceptScore W2136285655C2777025900 @default.
• W2136285655 hasConceptScore W2136285655C2778740770 @default.
• W2136285655 hasConceptScore W2136285655C2779013556 @default.
• W2136285655 hasConceptScore W2136285655C2780192828 @default.
• W2136285655 hasConceptScore W2136285655C2780849966 @default.
• W2136285655 hasConceptScore W2136285655C2780965494 @default.

• next