FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136309845> ?p ?o ?g. }

• W2136309845 endingPage "521" @default.
• W2136309845 startingPage "515" @default.
• W2136309845 abstract "A rapid mass spectrometric method was developed for the identification of fentanyl and its major hepatic metabolite norfentanyl in postmortem urine of six drug-overdose victims involving fentanyl use. To reduce matrix effects or ion suppression, sample preparation consisted of centrifugation and solid-phase extraction. Deuterium-labeled internal standards (2H5-fentanyl and 2H5-norfentanyl) were used to compensate for instrument variation in signal, analyte recovery during sample preparation, and ion suppression. Structural information for fentanyl and norfentanyl were collected using mass spectrometry (MS) with electrospray ionization (ESI) operated in the positive ion mode. Fentanyl (m/z 337) was found in each of the six overdose cases by the appearance of the MS-MS daughter ion on both an ion trap and a triple-quadrupole MS resulting from the fragmentation pathway of fentanyl (m/z 337 → 188). Norfentanyl was detected in all six cases by the appearance of the MH+ ion, m/z 233, with a single-quadrupole MS and confirmed in an ion trap MS. Ion suppression, as determined by the comparison of ion intensities from spiked samples in water with postmortem urine from the cases, ranged from 18% to 98% in three ESI sources. The use of stable isotope-labeled internal standards obviates sample preparation because ratios of analyte/internal standard remain constant in the presence of extensive matrix effects. This MS method provided sufficient sensitivity and selectivity for the rapid identification of fentanyl and norfentanyl in urine at levels ≥10 ng/mL without prior analyte resolution by chromatography and with a total analysis time of less than 1 h." @default.
• W2136309845 created "2016-06-24" @default.
• W2136309845 creator A5020893827 @default.
• W2136309845 creator A5021815921 @default.
• W2136309845 creator A5066089674 @default.
• W2136309845 creator A5077984843 @default.
• W2136309845 creator A5090853059 @default.
• W2136309845 date "2007-10-01" @default.
• W2136309845 modified "2023-09-26" @default.
• W2136309845 title "Direct-Injection Mass Spectrometric Method for the Rapid Identification of Fentanyl and Norfentanyl in Postmortem Urine of Six Drug-Overdose Cases" @default.
• W2136309845 cites W1965377187 @default.
• W2136309845 cites W1977706673 @default.
• W2136309845 cites W1990545609 @default.
• W2136309845 cites W1994770697 @default.
• W2136309845 cites W2000928266 @default.
• W2136309845 cites W2018115844 @default.
• W2136309845 cites W2023161477 @default.
• W2136309845 cites W2038554914 @default.
• W2136309845 cites W2038669670 @default.
• W2136309845 cites W2041575674 @default.
• W2136309845 cites W2046182332 @default.
• W2136309845 cites W2047213672 @default.
• W2136309845 cites W2047434559 @default.
• W2136309845 cites W2051080861 @default.
• W2136309845 cites W2059387518 @default.
• W2136309845 cites W2068843393 @default.
• W2136309845 cites W2070660871 @default.
• W2136309845 cites W2093266079 @default.
• W2136309845 cites W2113187612 @default.
• W2136309845 cites W2121028448 @default.
• W2136309845 cites W2141022288 @default.
• W2136309845 cites W2150928922 @default.
• W2136309845 cites W2152423888 @default.
• W2136309845 cites W2157679817 @default.
• W2136309845 cites W2165597960 @default.
• W2136309845 cites W2166166720 @default.
• W2136309845 cites W2167069808 @default.
• W2136309845 cites W2171809617 @default.
• W2136309845 doi "https://doi.org/10.1093/jat/31.8.515" @default.
• W2136309845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17988466" @default.
• W2136309845 hasPublicationYear "2007" @default.
• W2136309845 type Work @default.
• W2136309845 sameAs 2136309845 @default.
• W2136309845 citedByCount "22" @default.
• W2136309845 countsByYear W21363098452012 @default.
• W2136309845 countsByYear W21363098452014 @default.
• W2136309845 countsByYear W21363098452015 @default.
• W2136309845 countsByYear W21363098452016 @default.
• W2136309845 countsByYear W21363098452017 @default.
• W2136309845 countsByYear W21363098452020 @default.
• W2136309845 countsByYear W21363098452022 @default.
• W2136309845 countsByYear W21363098452023 @default.
• W2136309845 crossrefType "journal-article" @default.
• W2136309845 hasAuthorship W2136309845A5020893827 @default.
• W2136309845 hasAuthorship W2136309845A5021815921 @default.
• W2136309845 hasAuthorship W2136309845A5066089674 @default.
• W2136309845 hasAuthorship W2136309845A5077984843 @default.
• W2136309845 hasAuthorship W2136309845A5090853059 @default.
• W2136309845 hasBestOaLocation W21363098451 @default.
• W2136309845 hasConcept C10390740 @default.
• W2136309845 hasConcept C106289968 @default.
• W2136309845 hasConcept C113196181 @default.
• W2136309845 hasConcept C162356407 @default.
• W2136309845 hasConcept C175467004 @default.
• W2136309845 hasConcept C185592680 @default.
• W2136309845 hasConcept C2778576202 @default.
• W2136309845 hasConcept C2780026642 @default.
• W2136309845 hasConcept C2781072394 @default.
• W2136309845 hasConcept C31827203 @default.
• W2136309845 hasConcept C40684141 @default.
• W2136309845 hasConcept C43617362 @default.
• W2136309845 hasConcept C55493867 @default.
• W2136309845 hasConcept C71924100 @default.
• W2136309845 hasConcept C81426234 @default.
• W2136309845 hasConcept C98274493 @default.
• W2136309845 hasConceptScore W2136309845C10390740 @default.
• W2136309845 hasConceptScore W2136309845C106289968 @default.
• W2136309845 hasConceptScore W2136309845C113196181 @default.
• W2136309845 hasConceptScore W2136309845C162356407 @default.
• W2136309845 hasConceptScore W2136309845C175467004 @default.
• W2136309845 hasConceptScore W2136309845C185592680 @default.
• W2136309845 hasConceptScore W2136309845C2778576202 @default.
• W2136309845 hasConceptScore W2136309845C2780026642 @default.
• W2136309845 hasConceptScore W2136309845C2781072394 @default.
• W2136309845 hasConceptScore W2136309845C31827203 @default.
• W2136309845 hasConceptScore W2136309845C40684141 @default.
• W2136309845 hasConceptScore W2136309845C43617362 @default.
• W2136309845 hasConceptScore W2136309845C55493867 @default.
• W2136309845 hasConceptScore W2136309845C71924100 @default.
• W2136309845 hasConceptScore W2136309845C81426234 @default.
• W2136309845 hasConceptScore W2136309845C98274493 @default.
• W2136309845 hasIssue "8" @default.
• W2136309845 hasLocation W21363098451 @default.
• W2136309845 hasLocation W21363098452 @default.
• W2136309845 hasOpenAccess W2136309845 @default.
• W2136309845 hasPrimaryLocation W21363098451 @default.
• W2136309845 hasRelatedWork W1967565681 @default.
• W2136309845 hasRelatedWork W2004208954 @default.

• next