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• W2136317422 startingPage "3120" @default.
• W2136317422 abstract "ABSTRACT Serralysins are generally thought to function as pathogenicity factors of bacteria, but so far no hard evidence of this (e.g., specific substrate proteins that are sensitive to the cleavage by these proteases) has been found. We have looked for substrate proteins to a serralysin-type proteinase, PrtA, in a natural host-pathogen molecular interaction system involving Manduca sexta and Photorhabdus luminescens . The exposure in vitro of hemolymph to PrtA digestion resulted in selective cleavage of 16 proteins, provisionally termed PAT ( P rt A t arget) proteins. We could obtain sequence information for nine of these PrtA sensitive proteins, and by searching databases, we could identify six of them. Each has immune-related function involving every aspect of the immune defense: β-1,3 glucan recognition protein 2 (immune recognition), hemocyte aggregation inhibitor protein (HAIP), serine proteinase homolog 3, six serpin-1 variants, including serpin-1I (immune signaling and regulation), and scolexins A and B (coagulation cascade effector function). The functions of the identified PrtA substrate proteins shed new light on a possible participation of a serralysin in the virulence mechanism of a pathogen. Provided these proteins are targets of PrtA in vivo, this might represent, among others, a complex suppressive role on the innate immune response via interference with both the recognition and the elimination of the pathogen during the first, infective stage of the host-pathogen interaction. Our results also raise the possibility that the natural substrate proteins of serralysins of vertebrate pathogens might be found among the components of the innate immune system." @default.
• W2136317422 created "2016-06-24" @default.
• W2136317422 creator A5020968108 @default.
• W2136317422 creator A5066585688 @default.
• W2136317422 creator A5071132470 @default.
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• W2136317422 date "2009-05-15" @default.
• W2136317422 modified "2023-10-16" @default.
• W2136317422 title "Identification of Natural Target Proteins Indicates Functions of a Serralysin-Type Metalloprotease, PrtA, in Anti-Immune Mechanisms" @default.
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• W2136317422 doi "https://doi.org/10.1128/aem.02271-08" @default.
• W2136317422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2681659" @default.
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