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• W2136358623 abstract "Typhoid fever is a serious systemic infection caused by the enteric pathogen Salmonella enterica serovar typhi. WHO conservatively estimates the annual global incidence of typhoid fever at 21 million cases, of whom 1-4% end fatally. Keeping in consideration of increasing resistant of this disease to antibiotics and the limited available vaccine against salmonella infection, the need of the hour is to evaluate the efficacy of the natural plant products which can be useful for this disease. Salmonella typhimurium (S. typhimurium) causes an invasive disease in mice that has similarity with human typhoid. Mice pretreated orally with aqueous extract of Terminalia chebula at a dose of 500 mg/kg (T500) body wt for a period of 30 days exhibit a full protection against 100000 CFU of S. typhimurium injected intraperitonially. Mice pretreated with T500 for a period of 30 days followed by challenge with 50000 CFU of S. typhimurium also showed a reduction of 5.6% catalase activity and 97.69% in the level of lipid peroxidation (LPO) as compared to saline control mice subjected to same dose of bacteria. The same infected mice showed an increased level of reduced glutathione (GSH) by 62% as compared to the same saline control infected mice. The data indicated that regular intake of Terminalia chebula reduced the development of oxidative stress in mice and so can also reduce the risk of getting oxidative stress in S. typhi infection in man which finally reduces the possibility of getting typhoid fever." @default.
• W2136358623 created "2016-06-24" @default.
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• W2136358623 date "2009-01-01" @default.
• W2136358623 modified "2023-09-26" @default.
• W2136358623 title "Terminalia Chebula Reduces the Oxidative Stress Induced by Salmonella typhimurium in Mice and May Reduce the Risk of Getting Typhoid" @default.
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