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- W2136367022 abstract "Post translational modification of proteins is a critical requirement that regulates function. Among the diverse kinds of protein post translational modifications, phosphorylation plays essential roles in protein folding, protein:protein interactions, signal transduction, intracellular localization, transcription regulation, cell cycle progression, survival and apoptosis. Protein phosphorylation is also essential for many intracellular pathogens to establish a productive infection cycle. Preservation of protein phosphorylation moieties in pathogens in a manner that mirrors the host components underscores the co-evolutionary trajectory of pathogens and hosts, and sheds light on how successful pathogens have usurped, either in part or as a whole, the host enzymatic machinery. Phosphorylation of viral proteins for many acute RNA viruses including Flaviviruses and Alphaviruses has been demonstrated to be critical for protein functionality. This review focuses on phosphorylation modifications that have been documented to occur on viral proteins with emphasis on acutely infectious, single stranded RNA viruses. The review additionally explores the possibility of repurposing Food and Drug Administration (FDA) approved inhibitors as antivirals for the treatment of acute RNA viral infections." @default.
- W2136367022 created "2016-06-24" @default.
- W2136367022 creator A5003168818 @default.
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- W2136367022 creator A5037833018 @default.
- W2136367022 creator A5055970298 @default.
- W2136367022 creator A5067049222 @default.
- W2136367022 date "2015-10-12" @default.
- W2136367022 modified "2023-10-06" @default.
- W2136367022 title "Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies" @default.
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- W2136367022 doi "https://doi.org/10.3390/v7102872" @default.
- W2136367022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4632380" @default.
- W2136367022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26473910" @default.
- W2136367022 hasPublicationYear "2015" @default.
- W2136367022 type Work @default.