FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136378082> ?p ?o ?g. }

• W2136378082 endingPage "64" @default.
• W2136378082 startingPage "57" @default.
• W2136378082 abstract "Small interfering RNA (siRNA) has been widely used as potential therapeutic for treatment of various genetic disorders. However, rapid degradation, poor cellular uptake and limited stability in blood limit the effectiveness of the systemic delivery of siRNA. Therefore, an efficient delivery system is required to enhance its transfection and duration of therapeutics. In the present study, plasmid DNA (pEGFPN3) expressing green fluorescent protein (GFP) was used as a reporter gene. Chitosan nanoparticles/polyplexes and cationic liposomes/lipoplexes were developed and compared for their transfectivity and therapeutic activity in mammalian cell line (HEK 293). The nanoparticulates were first characterized by assessing the surface charge (zeta potential), size (dynamic light scattering) and morphology (transmission electron microscope) followed by evaluation for their DNA retardation ability, transfection efficiency and cytotoxicity on HEK 293 cell line. The chitosan nanoparticles/plasmid DNA (pDNA) complex and liposomes/pDNA complex were co-transfected with GFP-specific siRNA into HEK 293 cells and it was found that both are efficient delivery vehicles for siRNA transfection, resulting in ~57% and ~70% suppression of the targeted gene (GFP), respectively, as compared with the mock control (cells transfected with nanocarrier/pDNA complexes alone). This strong inhibition of GFP expression indicated that cationic liposomes are better than chitosan nanoparticles and can be used as an effective carrier of siRNA in mammalian cells." @default.
• W2136378082 created "2016-06-24" @default.
• W2136378082 creator A5030635639 @default.
• W2136378082 creator A5055731653 @default.
• W2136378082 creator A5061691357 @default.
• W2136378082 creator A5063117462 @default.
• W2136378082 creator A5087113599 @default.
• W2136378082 date "2013-02-01" @default.
• W2136378082 modified "2023-09-24" @default.
• W2136378082 title "Lipoplexes versus nanoparticles: pDNA/siRNA delivery" @default.
• W2136378082 cites W1498439983 @default.
• W2136378082 cites W1647075334 @default.
• W2136378082 cites W1969256416 @default.
• W2136378082 cites W1976811878 @default.
• W2136378082 cites W1979892444 @default.
• W2136378082 cites W1982944995 @default.
• W2136378082 cites W2013156289 @default.
• W2136378082 cites W2013998409 @default.
• W2136378082 cites W2015729243 @default.
• W2136378082 cites W2019387053 @default.
• W2136378082 cites W2029532796 @default.
• W2136378082 cites W2040714003 @default.
• W2136378082 cites W2041141014 @default.
• W2136378082 cites W2056568635 @default.
• W2136378082 cites W2080758920 @default.
• W2136378082 cites W2088849426 @default.
• W2136378082 cites W2092386113 @default.
• W2136378082 cites W2110538950 @default.
• W2136378082 cites W2160251401 @default.
• W2136378082 cites W2171757104 @default.
• W2136378082 cites W2767509363 @default.
• W2136378082 doi "https://doi.org/10.3109/10717544.2012.752419" @default.
• W2136378082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23537464" @default.
• W2136378082 hasPublicationYear "2013" @default.
• W2136378082 type Work @default.
• W2136378082 sameAs 2136378082 @default.
• W2136378082 citedByCount "17" @default.
• W2136378082 countsByYear W21363780822013 @default.
• W2136378082 countsByYear W21363780822015 @default.
• W2136378082 countsByYear W21363780822017 @default.
• W2136378082 countsByYear W21363780822018 @default.
• W2136378082 countsByYear W21363780822019 @default.
• W2136378082 countsByYear W21363780822020 @default.
• W2136378082 countsByYear W21363780822021 @default.
• W2136378082 countsByYear W21363780822022 @default.
• W2136378082 crossrefType "journal-article" @default.
• W2136378082 hasAuthorship W2136378082A5030635639 @default.
• W2136378082 hasAuthorship W2136378082A5055731653 @default.
• W2136378082 hasAuthorship W2136378082A5061691357 @default.
• W2136378082 hasAuthorship W2136378082A5063117462 @default.
• W2136378082 hasAuthorship W2136378082A5087113599 @default.
• W2136378082 hasBestOaLocation W21363780821 @default.
• W2136378082 hasConcept C104317684 @default.
• W2136378082 hasConcept C109316439 @default.
• W2136378082 hasConcept C12554922 @default.
• W2136378082 hasConcept C135983454 @default.
• W2136378082 hasConcept C142613039 @default.
• W2136378082 hasConcept C150194340 @default.
• W2136378082 hasConcept C153911025 @default.
• W2136378082 hasConcept C155672457 @default.
• W2136378082 hasConcept C155887181 @default.
• W2136378082 hasConcept C161733203 @default.
• W2136378082 hasConcept C171250308 @default.
• W2136378082 hasConcept C174510640 @default.
• W2136378082 hasConcept C18150654 @default.
• W2136378082 hasConcept C185154212 @default.
• W2136378082 hasConcept C185592680 @default.
• W2136378082 hasConcept C192562407 @default.
• W2136378082 hasConcept C202751555 @default.
• W2136378082 hasConcept C22615655 @default.
• W2136378082 hasConcept C2779732960 @default.
• W2136378082 hasConcept C54009773 @default.
• W2136378082 hasConcept C54355233 @default.
• W2136378082 hasConcept C55493867 @default.
• W2136378082 hasConcept C81885089 @default.
• W2136378082 hasConcept C86803240 @default.
• W2136378082 hasConcept C95444343 @default.
• W2136378082 hasConceptScore W2136378082C104317684 @default.
• W2136378082 hasConceptScore W2136378082C109316439 @default.
• W2136378082 hasConceptScore W2136378082C12554922 @default.
• W2136378082 hasConceptScore W2136378082C135983454 @default.
• W2136378082 hasConceptScore W2136378082C142613039 @default.
• W2136378082 hasConceptScore W2136378082C150194340 @default.
• W2136378082 hasConceptScore W2136378082C153911025 @default.
• W2136378082 hasConceptScore W2136378082C155672457 @default.
• W2136378082 hasConceptScore W2136378082C155887181 @default.
• W2136378082 hasConceptScore W2136378082C161733203 @default.
• W2136378082 hasConceptScore W2136378082C171250308 @default.
• W2136378082 hasConceptScore W2136378082C174510640 @default.
• W2136378082 hasConceptScore W2136378082C18150654 @default.
• W2136378082 hasConceptScore W2136378082C185154212 @default.
• W2136378082 hasConceptScore W2136378082C185592680 @default.
• W2136378082 hasConceptScore W2136378082C192562407 @default.
• W2136378082 hasConceptScore W2136378082C202751555 @default.
• W2136378082 hasConceptScore W2136378082C22615655 @default.
• W2136378082 hasConceptScore W2136378082C2779732960 @default.
• W2136378082 hasConceptScore W2136378082C54009773 @default.
• W2136378082 hasConceptScore W2136378082C54355233 @default.

• next