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• W2136381643 startingPage "581" @default.
• W2136381643 abstract "The history of the development of the analgestic drug acetaminophen is reviewed with an emphasis on the characteristics of its overdose toxicity. The P450-catalyzed oxidation of acetaminophen generates a reactive electrophile that binds covalently to proteins. Involvement of specific P450 enzymes in acetaminophen toxicity can be probed by experiments with knock-out mice. The identification of specific target proteins may help to clarify the mechanism of acetaminophen hepatoxocity." @default.
• W2136381643 created "2016-06-24" @default.
• W2136381643 creator A5026129168 @default.
• W2136381643 date "2005-01-01" @default.
• W2136381643 modified "2023-09-26" @default.
• W2136381643 title "The Molecular Toxicology of Acetaminophen" @default.
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• W2136381643 doi "https://doi.org/10.1080/03602530500205200" @default.
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