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• W2136388141 abstract "During a genome-wide screen with RNA-mediated interference, we isolated CG8580 as a gene involved in the innate immune response of Drosophila melanogaster. CG8580, which we called Akirin, encoded a protein that acted in parallel with the NF-κB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative bacteria. Akirin is highly conserved, and the human genome contains two homologs, one of which was able to rescue the loss-of-function phenotype in drosophila cells. Akirins were strictly localized to the nucleus. Knockout of both Akirin homologs in mice showed that one had an essential function downstream of the Toll-like receptor, tumor necrosis factor and interleukin (IL)-1β signaling pathways leading to the production of IL-6. Thus, Akirin is a conserved nuclear factor required for innate immune responses." @default.
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• W2136388141 date "2007-12-09" @default.
• W2136388141 modified "2023-10-12" @default.
• W2136388141 title "Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice" @default.
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• W2136388141 doi "https://doi.org/10.1038/ni1543" @default.
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