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- W2136392370 startingPage "F801" @default.
- W2136392370 abstract "Toll-like receptor-4 (TLR-4) has been increasingly recognized as playing a critical role in the pathogenesis of ischemia-reperfusion injury (IRI) of renal grafts. This review provides a detailed overview of the new understanding of the involvement of TLR-4 in ischemia-reperfusion injury of renal grafts and its clinical significance in renal transplantation. TLR-4 not only responds to exogenous microbial motifs but can also recognize molecules which are released by stressed and necrotic cells, as well as degraded products of endogenous macromolecules. Upregulation of TLR-4 is found in tubular epithelial cells, vascular endothelial cells, and infiltrating leukocytes during renal ischemia-reperfusion injury, which is induced by massive release of endogenous damage-associated molecular pattern molecules such as high-mobility group box chromosomal protein 1. Activation of TLR-4 promotes the release of proinflammatory mediators, facilitates leukocyte migration and infiltration, activates the innate and adaptive immune system, and potentiates renal fibrosis. TLR-4 inhibition serves as the target of pharmacological agents, which could attenuate ischemia-reperfusion injury and associated delayed graft function and allograft rejection. There is evidence in the literature showing that targeting TLR-4 could improve long-term transplantation outcomes. Given the pivotal role of TLR-4 in ischemia-reperfusion injury and associated delayed graft function and allograft rejection, inhibition of TLR-4 using pharmacological agents could be beneficial for long-term graft survival." @default.
- W2136392370 created "2016-06-24" @default.
- W2136392370 creator A5008357796 @default.
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- W2136392370 creator A5045711513 @default.
- W2136392370 creator A5052590910 @default.
- W2136392370 creator A5063968915 @default.
- W2136392370 date "2014-04-15" @default.
- W2136392370 modified "2023-10-16" @default.
- W2136392370 title "Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury" @default.
- W2136392370 cites W1488196937 @default.
- W2136392370 cites W1500063436 @default.
- W2136392370 cites W1520365933 @default.
- W2136392370 cites W1543556504 @default.
- W2136392370 cites W1964536962 @default.
- W2136392370 cites W1968166125 @default.
- W2136392370 cites W1970434640 @default.
- W2136392370 cites W1971521446 @default.
- W2136392370 cites W1972053601 @default.
- W2136392370 cites W1972204333 @default.
- W2136392370 cites W1973404097 @default.
- W2136392370 cites W1976505464 @default.
- W2136392370 cites W1981214429 @default.
- W2136392370 cites W1982297066 @default.
- W2136392370 cites W1985209496 @default.
- W2136392370 cites W1987383242 @default.
- W2136392370 cites W1988510020 @default.
- W2136392370 cites W1989656760 @default.
- W2136392370 cites W1991731944 @default.
- W2136392370 cites W1991987254 @default.
- W2136392370 cites W1999755139 @default.
- W2136392370 cites W2001477429 @default.
- W2136392370 cites W2007410147 @default.
- W2136392370 cites W2007671750 @default.
- W2136392370 cites W2009837507 @default.
- W2136392370 cites W2010453472 @default.
- W2136392370 cites W2011133581 @default.
- W2136392370 cites W2013127121 @default.
- W2136392370 cites W2018653121 @default.
- W2136392370 cites W2020557188 @default.
- W2136392370 cites W2028812270 @default.
- W2136392370 cites W2031913370 @default.
- W2136392370 cites W2033457930 @default.
- W2136392370 cites W2035809865 @default.
- W2136392370 cites W2036591640 @default.
- W2136392370 cites W2037605418 @default.
- W2136392370 cites W2037697863 @default.
- W2136392370 cites W2038073973 @default.
- W2136392370 cites W2042342255 @default.
- W2136392370 cites W2044264835 @default.
- W2136392370 cites W2047124888 @default.
- W2136392370 cites W2047759256 @default.
- W2136392370 cites W2048521033 @default.
- W2136392370 cites W2048618111 @default.
- W2136392370 cites W2050281416 @default.
- W2136392370 cites W2050419631 @default.
- W2136392370 cites W2050754168 @default.
- W2136392370 cites W2051969116 @default.
- W2136392370 cites W2052431369 @default.
- W2136392370 cites W2053907298 @default.
- W2136392370 cites W2054737428 @default.
- W2136392370 cites W2057368294 @default.
- W2136392370 cites W2058019632 @default.
- W2136392370 cites W2068419165 @default.
- W2136392370 cites W2068492703 @default.
- W2136392370 cites W2069605031 @default.
- W2136392370 cites W2070068969 @default.
- W2136392370 cites W2074131627 @default.
- W2136392370 cites W2075227250 @default.
- W2136392370 cites W2079935732 @default.
- W2136392370 cites W2081335280 @default.
- W2136392370 cites W2082333641 @default.
- W2136392370 cites W2083682196 @default.
- W2136392370 cites W2084276469 @default.
- W2136392370 cites W2085563179 @default.
- W2136392370 cites W2085638922 @default.
- W2136392370 cites W2085983608 @default.
- W2136392370 cites W2088699771 @default.
- W2136392370 cites W2094446254 @default.
- W2136392370 cites W2099230751 @default.
- W2136392370 cites W2101363646 @default.
- W2136392370 cites W2102664286 @default.
- W2136392370 cites W2107742731 @default.
- W2136392370 cites W2113769407 @default.
- W2136392370 cites W2113947795 @default.
- W2136392370 cites W2115185894 @default.
- W2136392370 cites W2123024844 @default.
- W2136392370 cites W2126659405 @default.
- W2136392370 cites W2129762934 @default.
- W2136392370 cites W2131698069 @default.
- W2136392370 cites W2138474497 @default.
- W2136392370 cites W2140655321 @default.
- W2136392370 cites W2142766154 @default.
- W2136392370 cites W2143461874 @default.
- W2136392370 cites W2144787399 @default.
- W2136392370 cites W2149576310 @default.
- W2136392370 cites W2150371282 @default.
- W2136392370 cites W2151652295 @default.