FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136445400> ?p ?o ?g. }

• W2136445400 endingPage "2088" @default.
• W2136445400 startingPage "2079" @default.
• W2136445400 abstract "ABSTRACT Burkholderia pseudomallei is an emerging bacterial pathogen and category B biothreat. Human infections with B. pseudomallei (called melioidosis) present as a range of manifestations, including acute septicemia and pneumonia. Although melioidosis can be fatal, little is known about the molecular basis of B. pseudomallei pathogenicity, in part because of the lack of simple, genetically tractable eukaryotic models to facilitate en masse identification of virulence determinants or explore host-pathogen interactions. Two assays, one high-throughput and one quantitative, were developed to monitor levels of resistance of B. pseudomallei and the closely related nearly avirulent species Burkholderia thailandensis to predation by the phagocytic amoeba Dictyostelium discoideum . The quantitative assay showed that levels of resistance to, and survival within, amoeba by these bacteria and their known virulence mutants correlate well with their published levels of virulence in animals. Using the high-throughput assay, we screened a 1,500-member B. thailandensis transposon mutant library and identified 13 genes involved in resistance to predation by D. discoideum . Orthologs of these genes were disrupted in B. pseudomallei , and nearly all mutants had similarly decreased resistance to predation by D. discoideum . For some mutants, decreased resistance also correlated with reduced survival in and cytotoxicity toward macrophages, as well as attenuated virulence in mice. These observations suggest that some factors required by B. pseudomallei for resistance to environmental phagocytes also aid in resistance to phagocytic immune cells and contribute to disease in animals. Thus, D. discoideum provides a novel, high-throughput model system for facilitating inquiry into B. pseudomallei virulence." @default.
• W2136445400 created "2016-06-24" @default.
• W2136445400 creator A5050048639 @default.
• W2136445400 creator A5068372151 @default.
• W2136445400 creator A5072705713 @default.
• W2136445400 date "2011-05-01" @default.
• W2136445400 modified "2023-09-27" @default.
• W2136445400 title "Dictyostelium discoideum as a Model System for Identification of Burkholderia pseudomallei Virulence Factors" @default.
• W2136445400 cites W1147879691 @default.
• W2136445400 cites W11572360 @default.
• W2136445400 cites W1512683046 @default.
• W2136445400 cites W1868922405 @default.
• W2136445400 cites W1970289402 @default.
• W2136445400 cites W1972038449 @default.
• W2136445400 cites W1980076571 @default.
• W2136445400 cites W1981161364 @default.
• W2136445400 cites W1983345355 @default.
• W2136445400 cites W1985542681 @default.
• W2136445400 cites W1987815733 @default.
• W2136445400 cites W1989760629 @default.
• W2136445400 cites W2000232525 @default.
• W2136445400 cites W2003824924 @default.
• W2136445400 cites W2006201918 @default.
• W2136445400 cites W2007230387 @default.
• W2136445400 cites W2007349675 @default.
• W2136445400 cites W2011148457 @default.
• W2136445400 cites W2013071065 @default.
• W2136445400 cites W2016913953 @default.
• W2136445400 cites W2027229485 @default.
• W2136445400 cites W2029664798 @default.
• W2136445400 cites W2033619721 @default.
• W2136445400 cites W2035399581 @default.
• W2136445400 cites W2035842134 @default.
• W2136445400 cites W2036221715 @default.
• W2136445400 cites W2037810159 @default.
• W2136445400 cites W2045388161 @default.
• W2136445400 cites W2046335528 @default.
• W2136445400 cites W2047153497 @default.
• W2136445400 cites W2050803324 @default.
• W2136445400 cites W2051165421 @default.
• W2136445400 cites W2051889688 @default.
• W2136445400 cites W2053416259 @default.
• W2136445400 cites W2058246783 @default.
• W2136445400 cites W2063048569 @default.
• W2136445400 cites W2071483627 @default.
• W2136445400 cites W2073002345 @default.
• W2136445400 cites W2074308942 @default.
• W2136445400 cites W2092468599 @default.
• W2136445400 cites W2097216778 @default.
• W2136445400 cites W2098598894 @default.
• W2136445400 cites W2098694771 @default.
• W2136445400 cites W2101891378 @default.
• W2136445400 cites W2102558489 @default.
• W2136445400 cites W2104752214 @default.
• W2136445400 cites W2104817697 @default.
• W2136445400 cites W2106816433 @default.
• W2136445400 cites W2108422054 @default.
• W2136445400 cites W2108657319 @default.
• W2136445400 cites W2113428334 @default.
• W2136445400 cites W2114835737 @default.
• W2136445400 cites W2116042511 @default.
• W2136445400 cites W2117551730 @default.
• W2136445400 cites W2121178227 @default.
• W2136445400 cites W2122270014 @default.
• W2136445400 cites W2130623712 @default.
• W2136445400 cites W2132370546 @default.
• W2136445400 cites W2132842206 @default.
• W2136445400 cites W2134212466 @default.
• W2136445400 cites W2139439431 @default.
• W2136445400 cites W2142666962 @default.
• W2136445400 cites W2155429253 @default.
• W2136445400 cites W2158400665 @default.
• W2136445400 cites W2158958374 @default.
• W2136445400 cites W2161645687 @default.
• W2136445400 cites W2164719325 @default.
• W2136445400 cites W2165731733 @default.
• W2136445400 cites W2166337090 @default.
• W2136445400 cites W2167727224 @default.
• W2136445400 cites W2168484570 @default.
• W2136445400 cites W2337233467 @default.
• W2136445400 cites W4245354300 @default.
• W2136445400 doi "https://doi.org/10.1128/iai.01233-10" @default.
• W2136445400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3088138" @default.
• W2136445400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21402765" @default.
• W2136445400 hasPublicationYear "2011" @default.
• W2136445400 type Work @default.
• W2136445400 sameAs 2136445400 @default.
• W2136445400 citedByCount "37" @default.
• W2136445400 countsByYear W21364454002012 @default.
• W2136445400 countsByYear W21364454002013 @default.
• W2136445400 countsByYear W21364454002014 @default.
• W2136445400 countsByYear W21364454002015 @default.
• W2136445400 countsByYear W21364454002016 @default.
• W2136445400 countsByYear W21364454002017 @default.
• W2136445400 countsByYear W21364454002018 @default.
• W2136445400 countsByYear W21364454002019 @default.
• W2136445400 countsByYear W21364454002020 @default.
• W2136445400 countsByYear W21364454002021 @default.

• next