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• W2136469630 endingPage "4493" @default.
• W2136469630 startingPage "4483" @default.
• W2136469630 abstract "In the leg and wing imaginal discs of Drosophila, the expression domains of the homeobox genes aristaless (al) and Distal-less (Dll) are defined by the secreted signaling molecules Wingless (Wg) and Decapentaplegic (Dpp). Here, the roles played by al and Dll in patterning the legs and wings have been investigated through loss of function studies. In the developing leg, al is expressed at the presumptive tip and a molecularly defined null allele of al reveals that its only function in patterning the leg appears to be to direct the growth and differentiation of the structures at the tip. In contrast, Dll has previously been shown to be required for the development of all of the leg more distal than the coxa. Dll protein can be detected in a central domain in leg discs throughout most of larval development, and in mature discs this domain corresponds to the distal-most region of the leg, the tarsus and the distal tibia. Clonal analysis reveals that late in development these are the only regions in which Dll function is required. However, earlier in development Dll is required in more proximal regions of the leg suggesting it is expressed at high levels in these cells early in development but not later. This reveals a correlation between a temporal requirement for Dll and position along the proximodistal axis; how this may relate to the generation of the P/D axis is discussed. Dll is required in the distal regions of the leg for the expression of tarsal-specific genes including al and bric-a-brac. Dll mutant cells in the leg sort out from wild-type cells suggesting one function of Dll here is to control adhesive properties of cells. Dll is also required for the normal development of the wing, primarily for the differentiation of the wing margin." @default.
• W2136469630 created "2016-06-24" @default.
• W2136469630 creator A5051870374 @default.
• W2136469630 creator A5065153302 @default.
• W2136469630 date "1998-11-15" @default.
• W2136469630 modified "2023-10-16" @default.
• W2136469630 title "The roles of the homeobox genes <i>aristaless</i> and <i>Distal-less</i> in patterning the legs and wings of <i>Drosophila</i>" @default.
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• W2136469630 doi "https://doi.org/10.1242/dev.125.22.4483" @default.
• W2136469630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9778507" @default.
• W2136469630 hasPublicationYear "1998" @default.
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