Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136484058> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2136484058 endingPage "169" @default.
- W2136484058 startingPage "161" @default.
- W2136484058 abstract "Both clinical and laboratory evidence in exposed seronegative (ESN) individuals to human HIV-1 has suggested the existence of mechanisms of natural resistance to the infection. A 32 base-pair deletion in the gene that codes for the CCR5, which is the main coreceptor for HIV-1, confers a high degree of resistance to HIV-1 infection. However, the genotype Delta32/Delta32 is present only in 2-4% of Caucasoid ESN individuals suggesting the existence of other mechanisms of protection. Mutations different from Delta32 have also been proposed as playing a role in resistance/susceptibility to this infection.To screen for different mutations along the entire coding region of the ccr5 gene that can potentially explain the persistent seronegativity in a group of ESN individuals.Of a total of 86 individuals analyzed for Delta32 mutation by the PCR technique, 36 scored HIV seropositive (SP) and 50 were ESN. The entire group of ESN individuals was screened for other mutations in the ccr5 gene by single strand conformational polymorphism (SSCP) and DNA sequencing.The frequency of the mutant allele Delta32 was 4% (4/100) for ESN individuals and 4.2% (3/72) for SP individuals. The homozygous mutant genotype (Delta32/Delta32) was found in only 2% (1/50) of ESN individuals, but in no SP individuals. The heterozygous genotype was found in 8.3% (3/36) of SP individuals and in 4% (2/50) of ESN individuals. The differences in the allelic and genotypic frequencies among the groups were not statistically significant. A comparison between the observed and the expected genotypic frequencies showed that they were significantly different for the ESN group, suggesting a protective, yet indirect effect of the mutant genotype.The screening of the entire coding region of the ccr5 gene in all ESN did not revealed no other mutations that could account for resistance to HIV-1 infection. Although the CCR5 molecule is the most important coreceptor for HIV-1, mutations in this gene do not account for most of the cases of natural resistance to this virus that have so far been reported." @default.
- W2136484058 created "2016-06-24" @default.
- W2136484058 creator A5000522424 @default.
- W2136484058 creator A5040707311 @default.
- W2136484058 creator A5043107998 @default.
- W2136484058 creator A5046912977 @default.
- W2136484058 creator A5077722860 @default.
- W2136484058 date "2002-01-01" @default.
- W2136484058 modified "2023-09-23" @default.
- W2136484058 title "Molecular characterization of the CCR 5 gene in seronegative individuals exposed to human immunodeficiency virus (HIV)" @default.
- W2136484058 cites W1517417834 @default.
- W2136484058 cites W1979149320 @default.
- W2136484058 cites W1986574361 @default.
- W2136484058 cites W1997390941 @default.
- W2136484058 cites W2007021820 @default.
- W2136484058 cites W2021932640 @default.
- W2136484058 cites W2038048329 @default.
- W2136484058 cites W2041978735 @default.
- W2136484058 cites W2042008364 @default.
- W2136484058 cites W2043842774 @default.
- W2136484058 cites W2045118483 @default.
- W2136484058 cites W2053600139 @default.
- W2136484058 cites W2071877014 @default.
- W2136484058 cites W2077787948 @default.
- W2136484058 cites W2078888764 @default.
- W2136484058 cites W2106915606 @default.
- W2136484058 cites W2110898276 @default.
- W2136484058 cites W2111105264 @default.
- W2136484058 cites W2120697664 @default.
- W2136484058 cites W2122575856 @default.
- W2136484058 cites W2124846613 @default.
- W2136484058 cites W2147169218 @default.
- W2136484058 cites W2149730509 @default.
- W2136484058 cites W2152453984 @default.
- W2136484058 cites W2165226694 @default.
- W2136484058 cites W2320498484 @default.
- W2136484058 cites W2327503296 @default.
- W2136484058 cites W2333260484 @default.
- W2136484058 cites W2342220526 @default.
- W2136484058 doi "https://doi.org/10.1016/s1386-6532(01)00219-0" @default.
- W2136484058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11595595" @default.
- W2136484058 hasPublicationYear "2002" @default.
- W2136484058 type Work @default.
- W2136484058 sameAs 2136484058 @default.
- W2136484058 citedByCount "19" @default.
- W2136484058 countsByYear W21364840582013 @default.
- W2136484058 countsByYear W21364840582015 @default.
- W2136484058 countsByYear W21364840582017 @default.
- W2136484058 countsByYear W21364840582018 @default.
- W2136484058 countsByYear W21364840582019 @default.
- W2136484058 countsByYear W21364840582020 @default.
- W2136484058 countsByYear W21364840582023 @default.
- W2136484058 crossrefType "journal-article" @default.
- W2136484058 hasAuthorship W2136484058A5000522424 @default.
- W2136484058 hasAuthorship W2136484058A5040707311 @default.
- W2136484058 hasAuthorship W2136484058A5043107998 @default.
- W2136484058 hasAuthorship W2136484058A5046912977 @default.
- W2136484058 hasAuthorship W2136484058A5077722860 @default.
- W2136484058 hasConcept C104317684 @default.
- W2136484058 hasConcept C135763542 @default.
- W2136484058 hasConcept C143065580 @default.
- W2136484058 hasConcept C159047783 @default.
- W2136484058 hasConcept C180754005 @default.
- W2136484058 hasConcept C3013748606 @default.
- W2136484058 hasConcept C501734568 @default.
- W2136484058 hasConcept C54355233 @default.
- W2136484058 hasConcept C86803240 @default.
- W2136484058 hasConceptScore W2136484058C104317684 @default.
- W2136484058 hasConceptScore W2136484058C135763542 @default.
- W2136484058 hasConceptScore W2136484058C143065580 @default.
- W2136484058 hasConceptScore W2136484058C159047783 @default.
- W2136484058 hasConceptScore W2136484058C180754005 @default.
- W2136484058 hasConceptScore W2136484058C3013748606 @default.
- W2136484058 hasConceptScore W2136484058C501734568 @default.
- W2136484058 hasConceptScore W2136484058C54355233 @default.
- W2136484058 hasConceptScore W2136484058C86803240 @default.
- W2136484058 hasIssue "3" @default.
- W2136484058 hasLocation W21364840581 @default.
- W2136484058 hasLocation W21364840582 @default.
- W2136484058 hasOpenAccess W2136484058 @default.
- W2136484058 hasPrimaryLocation W21364840581 @default.
- W2136484058 hasRelatedWork W101124211 @default.
- W2136484058 hasRelatedWork W1975253683 @default.
- W2136484058 hasRelatedWork W2057739827 @default.
- W2136484058 hasRelatedWork W2070922469 @default.
- W2136484058 hasRelatedWork W2091920404 @default.
- W2136484058 hasRelatedWork W2117110650 @default.
- W2136484058 hasRelatedWork W2147466517 @default.
- W2136484058 hasRelatedWork W2223919059 @default.
- W2136484058 hasRelatedWork W2883538728 @default.
- W2136484058 hasRelatedWork W3206047998 @default.
- W2136484058 hasVolume "23" @default.
- W2136484058 isParatext "false" @default.
- W2136484058 isRetracted "false" @default.
- W2136484058 magId "2136484058" @default.
- W2136484058 workType "article" @default.