FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136508875> ?p ?o ?g. }

• W2136508875 endingPage "920" @default.
• W2136508875 startingPage "909" @default.
• W2136508875 abstract "The C-type lectin receptor mMGL is expressed exclusively by myeloid antigen presenting cells (APC) such as dendritic cells (DC) and macrophages (Mφ), and it mediates binding to glycoproteins carrying terminal galactose and α- or β-N-acetylgalactosamine (Gal/GalNAc) residues. Trypanosoma cruzi (T. cruzi) expresses large amounts of mucin (TcMUC)-like glycoproteins. Here, we show by lectin-blot that galactose moieties are also expressed on the surface of T. cruzi. Male mMGL knockout (-/-) and wild-type (WT) C57BL/6 mice were infected intraperitoneally with 10(4) T. cruzi trypomastigotes (Queretaro strain). Following T. cruzi infection, mMGL-/- mice developed higher parasitemia and higher mortality rates compared with WT mice. Although hearts from T. cruzi-infected WT mice presented few amastigote nests, mMGL-/- mice displayed higher numbers of amastigote nests. Compared with WT, Mφ from mMGL-/- mice had low production of nitric oxide (NO), interleukin (IL)-12 and tumor necrosis factor (TNF)-α in response to soluble T. cruzi antigens (TcAg). Interestingly, upon in vitro T. cruzi infection, mMGL-/- Mφ expressed lower levels of MHC-II and TLR-4 and harbored higher numbers of parasites, even when mMGL-/- Mφ were previously primed with IFN-γ or LPS/IFN-γ. These data suggest that mMGL plays an important role during T. cruzi infection, is required for optimal Mφ activation, and may synergize with TLR-4-induced pathways to produce TNF-α, IL-1β and NO during the early phase of infection." @default.
• W2136508875 created "2016-06-24" @default.
• W2136508875 creator A5001152172 @default.
• W2136508875 creator A5003986089 @default.
• W2136508875 creator A5009189767 @default.
• W2136508875 creator A5056147023 @default.
• W2136508875 creator A5060963937 @default.
• W2136508875 creator A5063510856 @default.
• W2136508875 creator A5066389898 @default.
• W2136508875 creator A5074108990 @default.
• W2136508875 creator A5082146605 @default.
• W2136508875 creator A5084131412 @default.
• W2136508875 creator A5089645466 @default.
• W2136508875 creator A5073274163 @default.
• W2136508875 date "2014-01-01" @default.
• W2136508875 modified "2023-10-17" @default.
• W2136508875 title "Mouse Macrophage Galactose-type Lectin (mMGL) is Critical for Host Resistance against <i>Trypanosoma cruzi</i> Infection" @default.
• W2136508875 cites W1483947401 @default.
• W2136508875 cites W1489142574 @default.
• W2136508875 cites W1572573094 @default.
• W2136508875 cites W1575726260 @default.
• W2136508875 cites W1830641869 @default.
• W2136508875 cites W1870411326 @default.
• W2136508875 cites W1964144818 @default.
• W2136508875 cites W1968960259 @default.
• W2136508875 cites W1971835215 @default.
• W2136508875 cites W1976613469 @default.
• W2136508875 cites W1977682493 @default.
• W2136508875 cites W1978088299 @default.
• W2136508875 cites W1982293312 @default.
• W2136508875 cites W1982683553 @default.
• W2136508875 cites W1984553131 @default.
• W2136508875 cites W1986668504 @default.
• W2136508875 cites W2009203797 @default.
• W2136508875 cites W2021373467 @default.
• W2136508875 cites W2021480682 @default.
• W2136508875 cites W2026913350 @default.
• W2136508875 cites W2031278032 @default.
• W2136508875 cites W2031423487 @default.
• W2136508875 cites W2044279473 @default.
• W2136508875 cites W2046280963 @default.
• W2136508875 cites W2053261474 @default.
• W2136508875 cites W2053400250 @default.
• W2136508875 cites W2057156942 @default.
• W2136508875 cites W2066602623 @default.
• W2136508875 cites W2067736150 @default.
• W2136508875 cites W2070001514 @default.
• W2136508875 cites W2070417054 @default.
• W2136508875 cites W2072662862 @default.
• W2136508875 cites W2078701893 @default.
• W2136508875 cites W2086652136 @default.
• W2136508875 cites W2095842810 @default.
• W2136508875 cites W2100704940 @default.
• W2136508875 cites W2104667967 @default.
• W2136508875 cites W2115540287 @default.
• W2136508875 cites W2122513413 @default.
• W2136508875 cites W2123471676 @default.
• W2136508875 cites W2124270882 @default.
• W2136508875 cites W2126924404 @default.
• W2136508875 cites W2129374849 @default.
• W2136508875 cites W2131227412 @default.
• W2136508875 cites W2134046076 @default.
• W2136508875 cites W2138032601 @default.
• W2136508875 cites W2139134681 @default.
• W2136508875 cites W2141706559 @default.
• W2136508875 cites W2145631195 @default.
• W2136508875 cites W2148281263 @default.
• W2136508875 cites W2150640434 @default.
• W2136508875 cites W2151941382 @default.
• W2136508875 cites W2160660031 @default.
• W2136508875 cites W2161885008 @default.
• W2136508875 cites W2165049240 @default.
• W2136508875 cites W2165199797 @default.
• W2136508875 cites W2169819811 @default.
• W2136508875 cites W2170150820 @default.
• W2136508875 cites W2174282643 @default.
• W2136508875 doi "https://doi.org/10.7150/ijbs.9214" @default.
• W2136508875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4147224" @default.
• W2136508875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25170304" @default.
• W2136508875 hasPublicationYear "2014" @default.
• W2136508875 type Work @default.
• W2136508875 sameAs 2136508875 @default.
• W2136508875 citedByCount "16" @default.
• W2136508875 countsByYear W21365088752014 @default.
• W2136508875 countsByYear W21365088752016 @default.
• W2136508875 countsByYear W21365088752017 @default.
• W2136508875 countsByYear W21365088752018 @default.
• W2136508875 countsByYear W21365088752020 @default.
• W2136508875 countsByYear W21365088752021 @default.
• W2136508875 countsByYear W21365088752023 @default.
• W2136508875 crossrefType "journal-article" @default.
• W2136508875 hasAuthorship W2136508875A5001152172 @default.
• W2136508875 hasAuthorship W2136508875A5003986089 @default.
• W2136508875 hasAuthorship W2136508875A5009189767 @default.
• W2136508875 hasAuthorship W2136508875A5056147023 @default.
• W2136508875 hasAuthorship W2136508875A5060963937 @default.
• W2136508875 hasAuthorship W2136508875A5063510856 @default.
• W2136508875 hasAuthorship W2136508875A5066389898 @default.

• next