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• W2136509871 abstract "Some epidemiological and experimental studies suggest that consumption of resistant starch is preventive against colon cancer. Resistant starch leads to a fermentation-mediated increase in the formation of short-chain fatty acids, with a particularly high butyrate fraction in large bowel. Butyrate is considered to be protective against colon cancer because it causes growth arrest and apoptosis and regulates expression of proteins involved in cellular dedifferentiation in various tumor cell lines in culture. We sought to investigate these processes under conditions of a carcinogenicity experiment in vivo . In the present study, 1,2-dimethylhydrazine-treated Sprague–Dawley rats were fed standard diet ( n = 12) or diet with 10% hydrothermally modified Novelose 330 ® , a resistant starch type 3 (RS3), replacing digestible starch ( n = 8). After 20 weeks tumor number, epithelial proliferation, apoptosis, immunoreactivity of carcinogenesis-related proteins [protein kinase C-δ (PKC-δ), heat shock protein 25 (HSP25) and gastrointestinal glutathione peroxidase (GI-GPx)], as well as mucin properties were evaluated in proximal and distal colon in situ . No tumors developed under RS3 diet, compared to a tumor incidence of 0.6 ± 0.6 ( P < 0.05) under the standard diet. RS3 decreased the number of proliferating cells, the length of the proliferation zone and the total length of the crypt in the distal colon, but not proximal colon, and enhanced apoptosis in both colonic segments. It induced PKC-δ and HSP25 expression, but inhibited GI-GPx expression in the epithelium of distal colon. RS3 increased the number of predominantly acidic mucin containing goblet cells in the distal colon, but had no effect on the goblet cell count. We conclude that hydrothermally treated RS3 prevented colon carcinogenesis, and that this effect was mediated by enhanced apoptosis of damaged cells accompanied by changes in parameters of dedifferentiation in colonic mucosa." @default.
• W2136509871 created "2016-06-24" @default.
• W2136509871 creator A5059653387 @default.
• W2136509871 date "2006-04-05" @default.
• W2136509871 modified "2023-09-27" @default.
• W2136509871 title "Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon" @default.
• W2136509871 cites W1551321545 @default.
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• W2136509871 cites W1596026858 @default.
• W2136509871 cites W1856323793 @default.
• W2136509871 cites W1877854700 @default.
• W2136509871 cites W1931140155 @default.
• W2136509871 cites W1952459948 @default.
• W2136509871 cites W1956415993 @default.
• W2136509871 cites W1965536085 @default.
• W2136509871 cites W1966100640 @default.
• W2136509871 cites W1966342185 @default.
• W2136509871 cites W1968568577 @default.
• W2136509871 cites W1968858977 @default.
• W2136509871 cites W1970009307 @default.
• W2136509871 cites W1972491475 @default.
• W2136509871 cites W1973642609 @default.
• W2136509871 cites W1977307485 @default.
• W2136509871 cites W1977740052 @default.
• W2136509871 cites W1983393718 @default.
• W2136509871 cites W1985255836 @default.
• W2136509871 cites W1985691889 @default.
• W2136509871 cites W1987288556 @default.
• W2136509871 cites W1992002324 @default.
• W2136509871 cites W1992660699 @default.
• W2136509871 cites W1993299317 @default.
• W2136509871 cites W1999965011 @default.
• W2136509871 cites W2003614266 @default.
• W2136509871 cites W2007565925 @default.
• W2136509871 cites W2007783249 @default.
• W2136509871 cites W2007825194 @default.
• W2136509871 cites W2009616940 @default.
• W2136509871 cites W2014338935 @default.
• W2136509871 cites W2014835001 @default.
• W2136509871 cites W2017809653 @default.
• W2136509871 cites W2018047456 @default.
• W2136509871 cites W2018620221 @default.
• W2136509871 cites W2018627787 @default.
• W2136509871 cites W2018861313 @default.
• W2136509871 cites W2024375133 @default.
• W2136509871 cites W2032919245 @default.
• W2136509871 cites W2047679761 @default.
• W2136509871 cites W2058928754 @default.
• W2136509871 cites W2081046751 @default.
• W2136509871 cites W2082173679 @default.
• W2136509871 cites W2094034910 @default.
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• W2136509871 cites W2103446199 @default.
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• W2136509871 cites W2115219265 @default.
• W2136509871 cites W2117998622 @default.
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• W2136509871 cites W2140481880 @default.
• W2136509871 cites W2141048953 @default.
• W2136509871 cites W2146050671 @default.
• W2136509871 cites W2148420179 @default.
• W2136509871 cites W2148908418 @default.
• W2136509871 cites W2158971210 @default.
• W2136509871 cites W2159309845 @default.
• W2136509871 cites W2159610360 @default.
• W2136509871 cites W2160035649 @default.
• W2136509871 cites W2160759942 @default.
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• W2136509871 cites W2168433858 @default.
• W2136509871 cites W2170787360 @default.
• W2136509871 cites W2296179050 @default.
• W2136509871 cites W230075810 @default.
• W2136509871 cites W2402464922 @default.
• W2136509871 cites W3094434574 @default.
• W2136509871 cites W53048635 @default.
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• W2136509871 doi "https://doi.org/10.1093/carcin/bgl025" @default.
• W2136509871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16597648" @default.
• W2136509871 hasPublicationYear "2006" @default.
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