Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136522433> ?p ?o ?g. }
- W2136522433 endingPage "4995" @default.
- W2136522433 startingPage "4985" @default.
- W2136522433 abstract "Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the 1990s, and then waned until the availability in the past 5 years of monoclonal antibodies and small molecules that block the insulin-like growth factor 1 receptor. In this article, we review the history of insulin-like growth factors and their role in growth, development, organism survival, and in cancer, both epithelial cancers and sarcomas. Recent developments regarding phase I to II clinical trials of such agents are discussed, as well as potential studies to consider in the future, given the lack of efficacy of one such monoclonal antibody in combination with cytotoxic chemotherapy in a first-line study in metastatic non–small-cell lung adenocarcinoma. Greater success with these agents clinically is expected when combining the agents with inhibitors of other cell signaling pathways in which cross-resistance has been observed." @default.
- W2136522433 created "2016-06-24" @default.
- W2136522433 creator A5068677359 @default.
- W2136522433 date "2010-11-20" @default.
- W2136522433 modified "2023-09-26" @default.
- W2136522433 title "Small Is Beautiful: Insulin-Like Growth Factors and Their Role in Growth, Development, and Cancer" @default.
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