FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136527674> ?p ?o ?g. }

• W2136527674 endingPage "30" @default.
• W2136527674 startingPage "22" @default.
• W2136527674 abstract "Flavivirus infection as dengue and yellow fever persists as a terrible menace to pandemics, due to Aedes prevalence in the Americas. Yellow fever is characterized by hepatocyte damage, with steatosis, apoptosis and necrosis, mainly in the midzonal region of the liver, but the injury mechanism has not been studied at the light of recent knowledge, such as the advances in cell death mechanisms, inflammatory response and cytokine cell expression tools. We studied 53 human liver paraffin embedded blocks from patients who died with yellow fever, all with histological demonstration of higher prevalence of apoptosis over necrosis and mild disproportionate inflammatory response. Viral antigens were found most frequently in hepatocytes from the midzonal area than other lobule areas, as detected by specific immunohistochemistry. Infiltrating cell subpopulations showed mainly CD4+ T lymphocytes, with small numbers of CD8+ cytotoxic lymphocytes, CD20+ B lymphocytes, NKT+ cells and S100+ dendritic cells in the sites of inflammation, as compared to normal and leptospirosis liver blocks. Some cells expressed TNF-α and IFN-γ, but a much more intense proportion of TGF-β expressing cells were found, suggesting both a Th1 and Th3 patterns of immune response in yellow fever. Most affected hepatocyte presented apoptosis markers that appear at the cell death main pathway in this infection. Viral antigens, which production could interfere in hepatocyte biology, could induce the activation of apoptosis cascade, but TGF-β was also an apoptosis promoter. Our finding supports the key effect of the yellow fever virus in hepatocyte injury, resulting in prevalence of apoptosis over necrosis, aside from a TGF-β action induced by the inflammatory response." @default.
• W2136527674 created "2016-06-24" @default.
• W2136527674 creator A5005189442 @default.
• W2136527674 creator A5009662066 @default.
• W2136527674 creator A5018123789 @default.
• W2136527674 creator A5030748113 @default.
• W2136527674 creator A5038098823 @default.
• W2136527674 creator A5049658599 @default.
• W2136527674 creator A5058085588 @default.
• W2136527674 creator A5069960978 @default.
• W2136527674 creator A5083069554 @default.
• W2136527674 date "2006-02-01" @default.
• W2136527674 modified "2023-10-14" @default.
• W2136527674 title "Revisiting the liver in human yellow fever: Virus-induced apoptosis in hepatocytes associated with TGF-β, TNF-α and NK cells activity" @default.
• W2136527674 cites W14274566 @default.
• W2136527674 cites W1561176636 @default.
• W2136527674 cites W1877550103 @default.
• W2136527674 cites W1988426939 @default.
• W2136527674 cites W1998254297 @default.
• W2136527674 cites W2002624891 @default.
• W2136527674 cites W2044125681 @default.
• W2136527674 cites W2057741055 @default.
• W2136527674 cites W2088105997 @default.
• W2136527674 cites W2089890483 @default.
• W2136527674 cites W2094197406 @default.
• W2136527674 cites W2096428903 @default.
• W2136527674 cites W2105316737 @default.
• W2136527674 cites W2117676466 @default.
• W2136527674 cites W2118375382 @default.
• W2136527674 cites W2121374421 @default.
• W2136527674 cites W2121660182 @default.
• W2136527674 cites W2131788318 @default.
• W2136527674 cites W2141066880 @default.
• W2136527674 cites W2153928856 @default.
• W2136527674 cites W2158159015 @default.
• W2136527674 cites W2278793656 @default.
• W2136527674 cites W2326424320 @default.
• W2136527674 cites W2329383138 @default.
• W2136527674 cites W2339555239 @default.
• W2136527674 cites W2411528578 @default.
• W2136527674 cites W2421395535 @default.
• W2136527674 cites W2601183994 @default.
• W2136527674 cites W27043496 @default.
• W2136527674 cites W4247551550 @default.
• W2136527674 doi "https://doi.org/10.1016/j.virol.2005.09.058" @default.
• W2136527674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16278000" @default.
• W2136527674 hasPublicationYear "2006" @default.
• W2136527674 type Work @default.
• W2136527674 sameAs 2136527674 @default.
• W2136527674 citedByCount "116" @default.
• W2136527674 countsByYear W21365276742012 @default.
• W2136527674 countsByYear W21365276742013 @default.
• W2136527674 countsByYear W21365276742014 @default.
• W2136527674 countsByYear W21365276742015 @default.
• W2136527674 countsByYear W21365276742016 @default.
• W2136527674 countsByYear W21365276742017 @default.
• W2136527674 countsByYear W21365276742018 @default.
• W2136527674 countsByYear W21365276742019 @default.
• W2136527674 countsByYear W21365276742020 @default.
• W2136527674 countsByYear W21365276742021 @default.
• W2136527674 countsByYear W21365276742022 @default.
• W2136527674 countsByYear W21365276742023 @default.
• W2136527674 crossrefType "journal-article" @default.
• W2136527674 hasAuthorship W2136527674A5005189442 @default.
• W2136527674 hasAuthorship W2136527674A5009662066 @default.
• W2136527674 hasAuthorship W2136527674A5018123789 @default.
• W2136527674 hasAuthorship W2136527674A5030748113 @default.
• W2136527674 hasAuthorship W2136527674A5038098823 @default.
• W2136527674 hasAuthorship W2136527674A5049658599 @default.
• W2136527674 hasAuthorship W2136527674A5058085588 @default.
• W2136527674 hasAuthorship W2136527674A5069960978 @default.
• W2136527674 hasAuthorship W2136527674A5083069554 @default.
• W2136527674 hasBestOaLocation W21365276741 @default.
• W2136527674 hasConcept C147483822 @default.
• W2136527674 hasConcept C154317977 @default.
• W2136527674 hasConcept C159047783 @default.
• W2136527674 hasConcept C167672396 @default.
• W2136527674 hasConcept C17991360 @default.
• W2136527674 hasConcept C190283241 @default.
• W2136527674 hasConcept C202751555 @default.
• W2136527674 hasConcept C203014093 @default.
• W2136527674 hasConcept C2776200302 @default.
• W2136527674 hasConcept C2778690821 @default.
• W2136527674 hasConcept C31573885 @default.
• W2136527674 hasConcept C503630168 @default.
• W2136527674 hasConcept C54355233 @default.
• W2136527674 hasConcept C55493867 @default.
• W2136527674 hasConcept C86803240 @default.
• W2136527674 hasConcept C8891405 @default.
• W2136527674 hasConceptScore W2136527674C147483822 @default.
• W2136527674 hasConceptScore W2136527674C154317977 @default.
• W2136527674 hasConceptScore W2136527674C159047783 @default.
• W2136527674 hasConceptScore W2136527674C167672396 @default.
• W2136527674 hasConceptScore W2136527674C17991360 @default.
• W2136527674 hasConceptScore W2136527674C190283241 @default.
• W2136527674 hasConceptScore W2136527674C202751555 @default.
• W2136527674 hasConceptScore W2136527674C203014093 @default.
• W2136527674 hasConceptScore W2136527674C2776200302 @default.

• next