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- W2136543199 abstract "Abstract In contrast to peripheral lymphoid organs, in the liver a high proportion of T cells are CD4+NKT cells. We have previously reported that LFA-1 plays a pivotal role in the homing of thymic CD4+NKT cells to the liver. In the present study, we further assessed which cell type participates in the homing of thymic CD4+NKT cells to the liver. The accumulation of donor thymocyte-derived CD4+NKT cells in the liver of SCID mice that had been reconstituted with thymocytes from C57BL/6 mice was severely impaired by in vivo depletion of NK cells, but not Kupffer cells in recipients. These results suggest that NK cells participate in the homing of thymic CD4+NKT cells to the liver. We assume that LFA-1 expressed on NK cells is involved in this mechanism." @default.
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- W2136543199 date "2000-08-15" @default.
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- W2136543199 title "Cutting Edge: Contribution of NK Cells to the Homing of Thymic CD4+NKT Cells to the Liver" @default.
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- W2136543199 doi "https://doi.org/10.4049/jimmunol.165.4.1729" @default.
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