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- W2136543243 endingPage "418" @default.
- W2136543243 startingPage "409" @default.
- W2136543243 abstract "Diverticular disease (DD) is one of the most prevalent gastrointestinal disorders. The pathogenesis of diverticulosis and DD is controversially discussed. Current studies call the traditional concept of a fibre-deficient diet causing the development of diverticula into question. Data from two recent twin studies have provided conclusive evidence for a strong genetic component to diverticulosis. Although genomewide association studies have provided new insights into the polygenic architecture of human diseases, genomic research in diverticulosis and DD has just been started. This is an astonishing fact given the high morbidity and mortality of the disease, as well as the substantial economic burden on health care systems. For this review, we provide an update of the molecular pathobiology and summarise recent evidence supporting the hypothesis that distinct, yet unidentified genetic variants contribute to the development of diverticulosis and DD." @default.
- W2136543243 created "2016-06-24" @default.
- W2136543243 creator A5013003026 @default.
- W2136543243 creator A5055470252 @default.
- W2136543243 date "2015-10-01" @default.
- W2136543243 modified "2023-10-18" @default.
- W2136543243 title "The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence" @default.
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- W2136543243 doi "https://doi.org/10.1177/2050640615576676" @default.
- W2136543243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4625748" @default.
- W2136543243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26535118" @default.