FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136553882> ?p ?o ?g. }

• W2136553882 endingPage "6683" @default.
• W2136553882 startingPage "6679" @default.
• W2136553882 abstract "Camptothecin (CPT) analogs that form more stable ternary complexes with DNA and topoisomerase I (termed cleavable complexes) show greater activity in their ability to inhibit tumor cell line growth in preclinical studies. Based on our earlier work, we hypothesized that analogs bearing hydrogen bonding moieties at the 7- through 10-position of CPT would result in more stable cleavable complexes. Consequently, we synthesized analogs with 7-mono-, 7-di-, and 7-trihydroxymethylaminomethyl groups. These analogs showed increasing cleavable complex stability as the number of hydroxyl groups was increased. The 7-trihydroxymethylaminomethyl analog of 10,11-methylenedioxycamptothecin (THMAM-MD) showed remarkable ternary complex stability with a half-life of 116 minutes. This is an order of magnitude more stable than any previously examined analog. Our in vitro analysis demonstrated that these analogs were all potent topoisomerase I poisons and could inhibit tumor cell growth in culture. We studied the effects of THMAM-MD in vivo in severe combined immunodeficient mice bearing HT-29 colon cancer and MiaPaCa-2 pancreatic cancer tumors. The THMAM-MD analog showed excellent, persisting activity in inhibiting tumor growth with both lines. Taken together, our results suggest that CPTs with hydrophilic, hydrogen-bonding groups at the 7-position hold the promise of excellent clinical activity." @default.
• W2136553882 created "2016-06-24" @default.
• W2136553882 creator A5032558911 @default.
• W2136553882 creator A5037979147 @default.
• W2136553882 creator A5063097852 @default.
• W2136553882 creator A5071510058 @default.
• W2136553882 creator A5080900202 @default.
• W2136553882 creator A5083122170 @default.
• W2136553882 date "2004-09-15" @default.
• W2136553882 modified "2023-10-10" @default.
• W2136553882 title "Hydrophilic Camptothecin Analogs That Form Extremely Stable Cleavable Complexes with DNA and Topoisomerase I" @default.
• W2136553882 cites W1871475547 @default.
• W2136553882 cites W1966427792 @default.
• W2136553882 cites W1972222329 @default.
• W2136553882 cites W1984738096 @default.
• W2136553882 cites W2006853138 @default.
• W2136553882 cites W2027163634 @default.
• W2136553882 cites W2028231353 @default.
• W2136553882 cites W2031204173 @default.
• W2136553882 cites W2060286884 @default.
• W2136553882 cites W2071032119 @default.
• W2136553882 cites W2078751203 @default.
• W2136553882 cites W2080528351 @default.
• W2136553882 cites W2082439695 @default.
• W2136553882 cites W2090433937 @default.
• W2136553882 cites W2094337350 @default.
• W2136553882 cites W2114918609 @default.
• W2136553882 cites W2167354472 @default.
• W2136553882 cites W2186948489 @default.
• W2136553882 doi "https://doi.org/10.1158/0008-5472.can-04-1885" @default.
• W2136553882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15374984" @default.
• W2136553882 hasPublicationYear "2004" @default.
• W2136553882 type Work @default.
• W2136553882 sameAs 2136553882 @default.
• W2136553882 citedByCount "27" @default.
• W2136553882 countsByYear W21365538822012 @default.
• W2136553882 countsByYear W21365538822013 @default.
• W2136553882 countsByYear W21365538822014 @default.
• W2136553882 countsByYear W21365538822015 @default.
• W2136553882 countsByYear W21365538822016 @default.
• W2136553882 countsByYear W21365538822018 @default.
• W2136553882 countsByYear W21365538822021 @default.
• W2136553882 crossrefType "journal-article" @default.
• W2136553882 hasAuthorship W2136553882A5032558911 @default.
• W2136553882 hasAuthorship W2136553882A5037979147 @default.
• W2136553882 hasAuthorship W2136553882A5063097852 @default.
• W2136553882 hasAuthorship W2136553882A5071510058 @default.
• W2136553882 hasAuthorship W2136553882A5080900202 @default.
• W2136553882 hasAuthorship W2136553882A5083122170 @default.
• W2136553882 hasConcept C112887158 @default.
• W2136553882 hasConcept C147897179 @default.
• W2136553882 hasConcept C150903083 @default.
• W2136553882 hasConcept C178790620 @default.
• W2136553882 hasConcept C181199279 @default.
• W2136553882 hasConcept C185592680 @default.
• W2136553882 hasConcept C202751555 @default.
• W2136553882 hasConcept C207001950 @default.
• W2136553882 hasConcept C2776694085 @default.
• W2136553882 hasConcept C2778119113 @default.
• W2136553882 hasConcept C2779682216 @default.
• W2136553882 hasConcept C32909587 @default.
• W2136553882 hasConcept C54355233 @default.
• W2136553882 hasConcept C552990157 @default.
• W2136553882 hasConcept C55493867 @default.
• W2136553882 hasConcept C71240020 @default.
• W2136553882 hasConcept C81885089 @default.
• W2136553882 hasConcept C86756495 @default.
• W2136553882 hasConcept C86803240 @default.
• W2136553882 hasConcept C98274493 @default.
• W2136553882 hasConceptScore W2136553882C112887158 @default.
• W2136553882 hasConceptScore W2136553882C147897179 @default.
• W2136553882 hasConceptScore W2136553882C150903083 @default.
• W2136553882 hasConceptScore W2136553882C178790620 @default.
• W2136553882 hasConceptScore W2136553882C181199279 @default.
• W2136553882 hasConceptScore W2136553882C185592680 @default.
• W2136553882 hasConceptScore W2136553882C202751555 @default.
• W2136553882 hasConceptScore W2136553882C207001950 @default.
• W2136553882 hasConceptScore W2136553882C2776694085 @default.
• W2136553882 hasConceptScore W2136553882C2778119113 @default.
• W2136553882 hasConceptScore W2136553882C2779682216 @default.
• W2136553882 hasConceptScore W2136553882C32909587 @default.
• W2136553882 hasConceptScore W2136553882C54355233 @default.
• W2136553882 hasConceptScore W2136553882C552990157 @default.
• W2136553882 hasConceptScore W2136553882C55493867 @default.
• W2136553882 hasConceptScore W2136553882C71240020 @default.
• W2136553882 hasConceptScore W2136553882C81885089 @default.
• W2136553882 hasConceptScore W2136553882C86756495 @default.
• W2136553882 hasConceptScore W2136553882C86803240 @default.
• W2136553882 hasConceptScore W2136553882C98274493 @default.
• W2136553882 hasIssue "18" @default.
• W2136553882 hasLocation W21365538821 @default.
• W2136553882 hasLocation W21365538822 @default.
• W2136553882 hasOpenAccess W2136553882 @default.
• W2136553882 hasPrimaryLocation W21365538821 @default.
• W2136553882 hasRelatedWork W1541204074 @default.
• W2136553882 hasRelatedWork W1573325703 @default.
• W2136553882 hasRelatedWork W1968975825 @default.
• W2136553882 hasRelatedWork W2025290139 @default.

• next