FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136565720> ?p ?o ?g. }

• W2136565720 endingPage "2620" @default.
• W2136565720 startingPage "2612" @default.
• W2136565720 abstract "Monocytes and macrophages are the cell types most commonly associated with the innate immune response against Candida albicans infection. Interactions between the host immune system and Candida organisms have been investigated for planktonic Candida cells, but no studies have addressed these interactions in a biofilm environment. In this study, for the first time, we evaluated the ability of C. albicans to form biofilms in the presence or absence of adherent peripheral blood mononuclear cells (PBMCs; enriched for monocytes and macrophages by adherence). Our analyses using scanning electron and confocal scanning laser microscopy showed that the presence of PBMCs enhanced the ability of C. albicans to form biofilms and that the majority of PBMCs were localized to the basal and middle layers of the biofilm. In contrast to the interactions of PBMCs with planktonic C. albicans, where PBMCs phagocytose fungal cells, PBMCs did not appear to phagocytose fungal cells in biofilms. Furthermore, time-lapse laser microscopy revealed dynamic interactions between C. albicans and PBMCs in a biofilm. Additionally, we found that (i) only viable PBMCs influence Candida biofilm formation, (ii) cell surface components of PBMCs did not contribute to the enhancement of C. albicans biofilm, (iii) the biofilm-enhancing effect of PBMCs is mediated by a soluble factor released into the coculture medium of PBMCs with C. albicans, and (iv) supernatant collected from this coculture contained differential levels of pro- and anti-inflammatory cytokines. Our studies provide new insight into the interaction between Candida biofilm and host immune cells and demonstrate that immunocytes may influence the ability of C. albicans to form biofilms." @default.
• W2136565720 created "2016-06-24" @default.
• W2136565720 creator A5008580780 @default.
• W2136565720 creator A5033241128 @default.
• W2136565720 creator A5049239234 @default.
• W2136565720 creator A5081014269 @default.
• W2136565720 creator A5089635085 @default.
• W2136565720 date "2007-05-01" @default.
• W2136565720 modified "2023-10-10" @default.
• W2136565720 title "Interaction of<i>Candida albicans</i>with Adherent Human Peripheral Blood Mononuclear Cells Increases<i>C. albicans</i>Biofilm Formation and Results in Differential Expression of Pro- and Anti-Inflammatory Cytokines" @default.
• W2136565720 cites W13391543 @default.
• W2136565720 cites W1499921224 @default.
• W2136565720 cites W1511074270 @default.
• W2136565720 cites W1745270175 @default.
• W2136565720 cites W1772966975 @default.
• W2136565720 cites W1824211630 @default.
• W2136565720 cites W1891894356 @default.
• W2136565720 cites W1970294462 @default.
• W2136565720 cites W1976490405 @default.
• W2136565720 cites W1977074729 @default.
• W2136565720 cites W1980191732 @default.
• W2136565720 cites W1988156363 @default.
• W2136565720 cites W1995587581 @default.
• W2136565720 cites W2002836781 @default.
• W2136565720 cites W2005537124 @default.
• W2136565720 cites W2014061201 @default.
• W2136565720 cites W2017975787 @default.
• W2136565720 cites W2028025575 @default.
• W2136565720 cites W2034595187 @default.
• W2136565720 cites W2045197207 @default.
• W2136565720 cites W2056237149 @default.
• W2136565720 cites W2060736036 @default.
• W2136565720 cites W2085495600 @default.
• W2136565720 cites W2087580612 @default.
• W2136565720 cites W2089115810 @default.
• W2136565720 cites W2092032573 @default.
• W2136565720 cites W2106509498 @default.
• W2136565720 cites W2111172126 @default.
• W2136565720 cites W2114298708 @default.
• W2136565720 cites W2118236446 @default.
• W2136565720 cites W2118976825 @default.
• W2136565720 cites W2125848302 @default.
• W2136565720 cites W2129365470 @default.
• W2136565720 cites W2130028868 @default.
• W2136565720 cites W2130652548 @default.
• W2136565720 cites W2130941282 @default.
• W2136565720 cites W2132902808 @default.
• W2136565720 cites W2144129715 @default.
• W2136565720 cites W2144440398 @default.
• W2136565720 cites W2145928748 @default.
• W2136565720 cites W2148681378 @default.
• W2136565720 cites W2150014711 @default.
• W2136565720 cites W2152087265 @default.
• W2136565720 cites W2154430755 @default.
• W2136565720 cites W2156160379 @default.
• W2136565720 cites W2163803918 @default.
• W2136565720 cites W2164826387 @default.
• W2136565720 cites W2164872597 @default.
• W2136565720 cites W2171155970 @default.
• W2136565720 cites W2302365058 @default.
• W2136565720 cites W4211087629 @default.
• W2136565720 doi "https://doi.org/10.1128/iai.01841-06" @default.
• W2136565720 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1865760" @default.
• W2136565720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17339351" @default.
• W2136565720 hasPublicationYear "2007" @default.
• W2136565720 type Work @default.
• W2136565720 sameAs 2136565720 @default.
• W2136565720 citedByCount "118" @default.
• W2136565720 countsByYear W21365657202012 @default.
• W2136565720 countsByYear W21365657202013 @default.
• W2136565720 countsByYear W21365657202014 @default.
• W2136565720 countsByYear W21365657202015 @default.
• W2136565720 countsByYear W21365657202016 @default.
• W2136565720 countsByYear W21365657202017 @default.
• W2136565720 countsByYear W21365657202018 @default.
• W2136565720 countsByYear W21365657202019 @default.
• W2136565720 countsByYear W21365657202020 @default.
• W2136565720 countsByYear W21365657202021 @default.
• W2136565720 countsByYear W21365657202022 @default.
• W2136565720 countsByYear W21365657202023 @default.
• W2136565720 crossrefType "journal-article" @default.
• W2136565720 hasAuthorship W2136565720A5008580780 @default.
• W2136565720 hasAuthorship W2136565720A5033241128 @default.
• W2136565720 hasAuthorship W2136565720A5049239234 @default.
• W2136565720 hasAuthorship W2136565720A5081014269 @default.
• W2136565720 hasAuthorship W2136565720A5089635085 @default.
• W2136565720 hasBestOaLocation W21365657201 @default.
• W2136565720 hasConcept C136449434 @default.
• W2136565720 hasConcept C137061746 @default.
• W2136565720 hasConcept C145081991 @default.
• W2136565720 hasConcept C160448771 @default.
• W2136565720 hasConcept C202751555 @default.
• W2136565720 hasConcept C203014093 @default.
• W2136565720 hasConcept C2780917455 @default.
• W2136565720 hasConcept C2781184567 @default.
• W2136565720 hasConcept C523546767 @default.
• W2136565720 hasConcept C54355233 @default.
• W2136565720 hasConcept C55493867 @default.

• next