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• W2136565736 abstract "A hallmark of prion diseases is the accumulation of an abnormally folded prion protein, denoted PrP(Sc). Here we describe a new and highly sensitive method for the detection of PrP(Sc) in brain and other tissue samples that utilizes both PrP(Sc) diagnostic criteria in combination; protease resistance and aggregation. Upon filtration of tissue extracts derived from scrapie- or bovine spongiform encephalopathy-infected animals, PrP(Sc) is retained and detected on the membranes. Laborious steps such as SDS-PAGE and Western blotting are avoided with concomitant gain in sensitivity and reliability. The new procedure also proved useful in a screen for anti-prion compounds in a scrapie-infected cell culture model." @default.
• W2136565736 created "2016-06-24" @default.
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• W2136565736 date "2001-08-10" @default.
• W2136565736 modified "2023-09-26" @default.
• W2136565736 title "A sensitive filter retention assay for the detection of PrP^Scand the screening of anti-prion compounds" @default.
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• W2136565736 doi "https://doi.org/10.1016/s0014-5793(01)02692-8" @default.
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