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- W2136578541 abstract "A comparison was made in normal volunteers of measurements of glomerular filtration rate (G.F.R.) with 57 Co-B 12 and inulin. With the method of Cutler and Glatte (J. Lab. Clin. Med. 65,1041 (1965)), the mean ratio of 99 simultaneous renal clearances of 57 Co-B 12 and inulin was 0.43 in comparison with that of 0.88 averaged from six published reports. During clearances, the fraction of vitamin bound to plasma protein averaged 57% in our studies with a dextran–charcoal method to measure binding, compared with a 16% average in reports where exhaustive dialysis was used. Correction of clearances for unbound 57 Co-B 12 estimated by coated-charcoal adsorption resulted in a mean ratio of free B 12 to inulin clearances of 1.0 in two patients. Because of the difference in 57 Co-B 12 binding in our patients compared with others, we studied three methods of determining the binding of vitamin B 12 added to plasma in vitro in concentrations of 0.2 to 2000.0 ng/ml. With all three techniques, ultrafiltration, dextran-coated charcoal adsorption, and exhaustive dialysis, the percent of added 57 Co-B 12 bound to plasma decreased with increasing concentrations of vitamin. At concentrations above 20.0 ng/ml, binding differed with each technique. The highest binding was observed with ultrafiltration, the lowest with exhaustive dialysis. Dilution of the plasma or reduction of incubation temperatures from 37 °C to 20 °C reduced the amount bound. Studies of binding of 57 Co-B 12 in our patients showed a variation with time. Unless binding is measured for each clearance period by a standardized technique, 57 Co-B 12 should not be used as a replacement for inulin in the measurement of G.F.R." @default.
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- W2136578541 date "1969-04-01" @default.
- W2136578541 modified "2023-09-26" @default.
- W2136578541 title "Determination of glomerular filtration rate with 57Co-B12 and plasma protein binding of cyanocobalamin" @default.
- W2136578541 doi "https://doi.org/10.1139/y69-063" @default.
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