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• W2136586210 abstract "A sex difference in surfactant lipids is associated with a higher incidence of respiratory distress syndrome for males in cases of preterm birth. In animal models, the sex difference in surfactant lipids was shown to be androgen receptor-dependent. This report examines expression of apolipoprotein (apo)A-I, apoA-II, apoC-II, apoE, apoH, and lipoprotein lipase (LPL) by quantitative real-time PCR in pools of male and female fetal lung tissues from various mouse litters from gestation day (GD) 15.5 to 18.5, and in various adult tissues. Although the expression profiles of ApoA-I , ApoA-II , ApoC-II , and ApoH are complex, these genes are co-regulated and they all present a sex difference ( P =0.0896, 0.0896, 0.0195, and 0.0607 respectively) with higher expression for females for several litters. Pulmonary expression of apoA-I, apoA-II, and apoH were specific to the developing lung. ApoE and LPL mRNAs showed a significant increase from GD 17.5 to 18.5. An increase in apoA-I-, apoA-II-, apoC-II-, and apoH-mRNA accumulation was observed from GD 16.5 to 17.5 in correlation with the emergence of mature type II pneumonocytes. These four apolipoprotein genes are co-regulated with type 2 and 5 17β-hydroxysteroid dehydrogenases, which are respectively involved in inactivation and synthesis of androgens. Finally, apoC-II was detected by immunohistochemistry in epithelial cells of the distal epithelium. Positive signals looking like secretory granules were located near the basal membrane. Our results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis." @default.
• W2136586210 created "2016-06-24" @default.
• W2136586210 creator A5013191249 @default.
• W2136586210 creator A5032012791 @default.
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• W2136586210 date "2008-12-23" @default.
• W2136586210 modified "2023-10-16" @default.
• W2136586210 title "Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids" @default.
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• W2136586210 doi "https://doi.org/10.1677/joe-08-0238" @default.
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