FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136632411> ?p ?o ?g. }

• W2136632411 endingPage "71" @default.
• W2136632411 startingPage "68" @default.
• W2136632411 abstract "Myeloperoxidase-chloride-H2O2 antimicrobial system is an integral part of leukocyte defense against pathogenic microorganisms. The system is present in gingival crevicular fluid and in whole saliva and, thus, possibly contributes to the non-antibody defense in the human mouth. In fact, at physiological concentrations myeloperoxidase-Cl−-H2O2 system effectively killed Streptococcus mutans both at acid and neutral pH. However, thiocyanate (SCN−) ions at concentrations similar to those in human saliva abolished this bactericidal action indicating that SCN− rather than Cl− is the physiologic substrate of myeloperoxidase in whole saliva. The peroxidation of SCN− (by myeloperoxidase or salivary peroxidase) yields oxidation products which inhibit the growth and metabolism of S. mutans without notable loss of cell viability. Our results suggest that the presence of SCN− in saliva protects human oral tissues (and bacteria) from highly cytotoxic oxidation products of Cl− and, instead, bacteriostatic and non-toxic oxidation products of SCN− are generated. In the gingival crevices, however, the SCN−/ Cl− ratio may be too small for effective block of Cl− oxidation by myeloperoxidase, and the oxidation products of Cl−, such as hypochlorite or hypochlorous acid, may contribute to the breakdown of periodontal tissues during inflammation." @default.
• W2136632411 created "2016-06-24" @default.
• W2136632411 creator A5020665471 @default.
• W2136632411 creator A5035971141 @default.
• W2136632411 creator A5070844208 @default.
• W2136632411 creator A5073495378 @default.
• W2136632411 date "1988-06-01" @default.
• W2136632411 modified "2023-09-26" @default.
• W2136632411 title "Antibacterial effect of myeloperoxidase against Streptococcus mutans" @default.
• W2136632411 cites W1489538734 @default.
• W2136632411 cites W1538818159 @default.
• W2136632411 cites W1581010225 @default.
• W2136632411 cites W1586360287 @default.
• W2136632411 cites W1839155169 @default.
• W2136632411 cites W1839923189 @default.
• W2136632411 cites W1943262283 @default.
• W2136632411 cites W1950783987 @default.
• W2136632411 cites W1967451740 @default.
• W2136632411 cites W1981006181 @default.
• W2136632411 cites W1988981294 @default.
• W2136632411 cites W1996115891 @default.
• W2136632411 cites W1996242059 @default.
• W2136632411 cites W1997449896 @default.
• W2136632411 cites W1999568744 @default.
• W2136632411 cites W2000309967 @default.
• W2136632411 cites W2021879632 @default.
• W2136632411 cites W2024580143 @default.
• W2136632411 cites W2027548474 @default.
• W2136632411 cites W2032126752 @default.
• W2136632411 cites W2063258491 @default.
• W2136632411 cites W2067431242 @default.
• W2136632411 cites W2071036740 @default.
• W2136632411 cites W2072388521 @default.
• W2136632411 cites W2078502281 @default.
• W2136632411 cites W2082549776 @default.
• W2136632411 cites W2098501605 @default.
• W2136632411 cites W2109173122 @default.
• W2136632411 cites W2113444966 @default.
• W2136632411 cites W2131643198 @default.
• W2136632411 cites W2168828646 @default.
• W2136632411 doi "https://doi.org/10.1111/j.1399-302x.1988.tb00084.x" @default.
• W2136632411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2855860" @default.
• W2136632411 hasPublicationYear "1988" @default.
• W2136632411 type Work @default.
• W2136632411 sameAs 2136632411 @default.
• W2136632411 citedByCount "25" @default.
• W2136632411 countsByYear W21366324112012 @default.
• W2136632411 countsByYear W21366324112013 @default.
• W2136632411 countsByYear W21366324112014 @default.
• W2136632411 countsByYear W21366324112017 @default.
• W2136632411 countsByYear W21366324112022 @default.
• W2136632411 crossrefType "journal-article" @default.
• W2136632411 hasAuthorship W2136632411A5020665471 @default.
• W2136632411 hasAuthorship W2136632411A5035971141 @default.
• W2136632411 hasAuthorship W2136632411A5070844208 @default.
• W2136632411 hasAuthorship W2136632411A5073495378 @default.
• W2136632411 hasConcept C162008176 @default.
• W2136632411 hasConcept C178790620 @default.
• W2136632411 hasConcept C181199279 @default.
• W2136632411 hasConcept C185592680 @default.
• W2136632411 hasConcept C203014093 @default.
• W2136632411 hasConcept C203565725 @default.
• W2136632411 hasConcept C2776294642 @default.
• W2136632411 hasConcept C2776832558 @default.
• W2136632411 hasConcept C2776914184 @default.
• W2136632411 hasConcept C2778430296 @default.
• W2136632411 hasConcept C2780908991 @default.
• W2136632411 hasConcept C504460877 @default.
• W2136632411 hasConcept C523546767 @default.
• W2136632411 hasConcept C54355233 @default.
• W2136632411 hasConcept C55493867 @default.
• W2136632411 hasConcept C86803240 @default.
• W2136632411 hasConcept C89423630 @default.
• W2136632411 hasConceptScore W2136632411C162008176 @default.
• W2136632411 hasConceptScore W2136632411C178790620 @default.
• W2136632411 hasConceptScore W2136632411C181199279 @default.
• W2136632411 hasConceptScore W2136632411C185592680 @default.
• W2136632411 hasConceptScore W2136632411C203014093 @default.
• W2136632411 hasConceptScore W2136632411C203565725 @default.
• W2136632411 hasConceptScore W2136632411C2776294642 @default.
• W2136632411 hasConceptScore W2136632411C2776832558 @default.
• W2136632411 hasConceptScore W2136632411C2776914184 @default.
• W2136632411 hasConceptScore W2136632411C2778430296 @default.
• W2136632411 hasConceptScore W2136632411C2780908991 @default.
• W2136632411 hasConceptScore W2136632411C504460877 @default.
• W2136632411 hasConceptScore W2136632411C523546767 @default.
• W2136632411 hasConceptScore W2136632411C54355233 @default.
• W2136632411 hasConceptScore W2136632411C55493867 @default.
• W2136632411 hasConceptScore W2136632411C86803240 @default.
• W2136632411 hasConceptScore W2136632411C89423630 @default.
• W2136632411 hasIssue "2" @default.
• W2136632411 hasLocation W21366324111 @default.
• W2136632411 hasLocation W21366324112 @default.
• W2136632411 hasOpenAccess W2136632411 @default.
• W2136632411 hasPrimaryLocation W21366324111 @default.
• W2136632411 hasRelatedWork W1489538734 @default.
• W2136632411 hasRelatedWork W1523094201 @default.
• W2136632411 hasRelatedWork W1934982504 @default.

• next