FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136648615> ?p ?o ?g. }

• W2136648615 endingPage "443" @default.
• W2136648615 startingPage "423" @default.
• W2136648615 abstract "Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal neoplasia. Some polymorphic genes involved in folate metabolism--methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair insertion), and thymidylate synthase (TS enhancer region and 3' untranslated region)--have been investigated in colorectal neoplasia. For MTHFR C677T and A1298C, the variant allele is associated with reduced enzyme activity in vitro. For the other polymorphisms, functional data are limited and/or inconsistent. Genotype frequencies for all of the polymorphisms show marked ethnic and geographic variation. In most studies, MTHFR 677TT (10 studies, >4,000 cases) and 1298CC (four studies, >1,500 cases) are associated with moderately reduced colorectal cancer risk. In four of five genotype-diet interaction studies, 677TT subjects who had higher folate levels (or a high-methyl diet) had the lowest cancer risk. In two studies, 677TT homozygote subjects with the highest alcohol intake had the highest cancer risk. Findings from six studies of MTHFR C677T and adenomatous polyps are inconsistent. There have been only one or two studies of the other polymorphisms; replication is needed. Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested." @default.
• W2136648615 created "2016-06-24" @default.
• W2136648615 creator A5073764742 @default.
• W2136648615 creator A5085045412 @default.
• W2136648615 date "2004-03-01" @default.
• W2136648615 modified "2023-10-05" @default.
• W2136648615 title "Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia: A HuGE Review" @default.
• W2136648615 cites W121028119 @default.
• W2136648615 cites W1492157159 @default.
• W2136648615 cites W1495781081 @default.
• W2136648615 cites W1572305422 @default.
• W2136648615 cites W1576681682 @default.
• W2136648615 cites W1593442063 @default.
• W2136648615 cites W1690786713 @default.
• W2136648615 cites W1712612878 @default.
• W2136648615 cites W1787707855 @default.
• W2136648615 cites W180278647 @default.
• W2136648615 cites W1820069114 @default.
• W2136648615 cites W1832874051 @default.
• W2136648615 cites W1845635598 @default.
• W2136648615 cites W1895997920 @default.
• W2136648615 cites W1896287471 @default.
• W2136648615 cites W1925208328 @default.
• W2136648615 cites W1925282661 @default.
• W2136648615 cites W1926500288 @default.
• W2136648615 cites W1935994339 @default.
• W2136648615 cites W1954873734 @default.
• W2136648615 cites W1963595709 @default.
• W2136648615 cites W1963978213 @default.
• W2136648615 cites W1965788840 @default.
• W2136648615 cites W1966251853 @default.
• W2136648615 cites W1968999014 @default.
• W2136648615 cites W1972685913 @default.
• W2136648615 cites W1974174480 @default.
• W2136648615 cites W1974327598 @default.
• W2136648615 cites W1975595363 @default.
• W2136648615 cites W1976205360 @default.
• W2136648615 cites W1977879763 @default.
• W2136648615 cites W1982169303 @default.
• W2136648615 cites W1983419413 @default.
• W2136648615 cites W1985857062 @default.
• W2136648615 cites W1986621591 @default.
• W2136648615 cites W1986795920 @default.
• W2136648615 cites W1988675954 @default.
• W2136648615 cites W1989423687 @default.
• W2136648615 cites W1990175546 @default.
• W2136648615 cites W1990763949 @default.
• W2136648615 cites W1991665938 @default.
• W2136648615 cites W1991882983 @default.
• W2136648615 cites W1994556109 @default.
• W2136648615 cites W1994709586 @default.
• W2136648615 cites W1994914421 @default.
• W2136648615 cites W1997797062 @default.
• W2136648615 cites W2001337137 @default.
• W2136648615 cites W2001525363 @default.
• W2136648615 cites W2010202776 @default.
• W2136648615 cites W2011006722 @default.
• W2136648615 cites W2011466084 @default.
• W2136648615 cites W2011498006 @default.
• W2136648615 cites W2012851256 @default.
• W2136648615 cites W2017325297 @default.
• W2136648615 cites W2018480908 @default.
• W2136648615 cites W2023025627 @default.
• W2136648615 cites W2023112726 @default.
• W2136648615 cites W2023172570 @default.
• W2136648615 cites W2025231171 @default.
• W2136648615 cites W2026305011 @default.
• W2136648615 cites W2027069016 @default.
• W2136648615 cites W2027141959 @default.
• W2136648615 cites W2028260095 @default.
• W2136648615 cites W2029513761 @default.
• W2136648615 cites W2032480351 @default.
• W2136648615 cites W2033881351 @default.
• W2136648615 cites W2035543497 @default.
• W2136648615 cites W2037501837 @default.
• W2136648615 cites W2038895741 @default.
• W2136648615 cites W2039375931 @default.
• W2136648615 cites W2040177918 @default.
• W2136648615 cites W2040730922 @default.
• W2136648615 cites W2041751912 @default.
• W2136648615 cites W2044170424 @default.
• W2136648615 cites W2045105685 @default.
• W2136648615 cites W2048436571 @default.
• W2136648615 cites W2048731329 @default.
• W2136648615 cites W2049439467 @default.
• W2136648615 cites W2051054384 @default.
• W2136648615 cites W2051836198 @default.
• W2136648615 cites W2052086138 @default.
• W2136648615 cites W2052666229 @default.
• W2136648615 cites W2057228725 @default.
• W2136648615 cites W2059072983 @default.
• W2136648615 cites W2059514904 @default.
• W2136648615 cites W2060350507 @default.
• W2136648615 cites W2065435420 @default.
• W2136648615 cites W2066688265 @default.
• W2136648615 cites W2069320022 @default.
• W2136648615 cites W2069487228 @default.
• W2136648615 cites W2070620209 @default.

• next