Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136670774> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2136670774 endingPage "1227" @default.
- W2136670774 startingPage "1225" @default.
- W2136670774 abstract "BACKGROUND--The association of nocturnal asthma symptoms with a diurnal increase in inflammatory activity suggests a role for anti-inflammatory therapy in nocturnal asthma. METHODS--Fifty patients with asthma with nocturnal symptoms entered a randomised, double blind, placebo controlled, crossover study. After a two week baseline period patients received nedocromil sodium (4 mg) or placebo four times daily. After eight weeks of treatment patients crossed to the alternative treatment for a further eight weeks. Symptom severity was recorded on a scale of 0-4 and inhaled bronchodilator use and peak flow (PEFR) were also recorded daily by the patients. Asthma severity, pulmonary function (FEV1, PEFR, FVC), and adverse events were recorded at clinic visits (baseline and after four and eight weeks of treatment). Global effectiveness was rated by clinician and patient, and treatment preference was recorded. RESULTS--Efficacy was assessed from data from 28 patients. Night-time asthma (mean (SE) difference between nedocromil sodium and placebo: -0.52 (0.13)), total nocturnal symptom severity defined as night-time asthma plus morning tightness (-0.72 (0.20)), and night-time bronchodilator use (-0.62 (0.23)) were reduced with nedocromil sodium compared with placebo treatment during the primary efficacy period (weeks 5-8) and during weeks 1-4 (-0.36 (0.12), -0.63 (0.20), and -0.55 (0.28), respectively). Morning and evening PEFR values improved slightly--but not significantly--compared with placebo. Patient and clinician opinions favoured nedocromil sodium treatment. Daytime asthma, daytime cough, and clinic assessment of asthma severity (secondary efficacy variables) were improved with nedocromil sodium treatment; day-time bronchodilator use and clinic pulmonary function were not. CONCLUSIONS--Nedocromil sodium was more effective than placebo in reducing nocturnal symptoms of asthma and bronchodilator use in this group of patients." @default.
- W2136670774 created "2016-06-24" @default.
- W2136670774 creator A5051764569 @default.
- W2136670774 creator A5062921637 @default.
- W2136670774 date "1994-12-01" @default.
- W2136670774 modified "2023-09-26" @default.
- W2136670774 title "Treatment of nocturnal asthma with nedocromil sodium." @default.
- W2136670774 cites W1961949026 @default.
- W2136670774 cites W2079336364 @default.
- W2136670774 cites W4230712966 @default.
- W2136670774 cites W4231944560 @default.
- W2136670774 cites W96992438 @default.
- W2136670774 doi "https://doi.org/10.1136/thx.49.12.1225" @default.
- W2136670774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/475328" @default.
- W2136670774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7878557" @default.
- W2136670774 hasPublicationYear "1994" @default.
- W2136670774 type Work @default.
- W2136670774 sameAs 2136670774 @default.
- W2136670774 citedByCount "11" @default.
- W2136670774 countsByYear W21366707742020 @default.
- W2136670774 crossrefType "journal-article" @default.
- W2136670774 hasAuthorship W2136670774A5051764569 @default.
- W2136670774 hasAuthorship W2136670774A5062921637 @default.
- W2136670774 hasBestOaLocation W21366707741 @default.
- W2136670774 hasConcept C121332964 @default.
- W2136670774 hasConcept C126322002 @default.
- W2136670774 hasConcept C1276947 @default.
- W2136670774 hasConcept C142724271 @default.
- W2136670774 hasConcept C19720800 @default.
- W2136670774 hasConcept C204787440 @default.
- W2136670774 hasConcept C27081682 @default.
- W2136670774 hasConcept C2776002719 @default.
- W2136670774 hasConcept C2776042228 @default.
- W2136670774 hasConcept C2776476923 @default.
- W2136670774 hasConcept C2781018748 @default.
- W2136670774 hasConcept C2910070530 @default.
- W2136670774 hasConcept C42219234 @default.
- W2136670774 hasConcept C71924100 @default.
- W2136670774 hasConcept C75603125 @default.
- W2136670774 hasConcept C87813604 @default.
- W2136670774 hasConceptScore W2136670774C121332964 @default.
- W2136670774 hasConceptScore W2136670774C126322002 @default.
- W2136670774 hasConceptScore W2136670774C1276947 @default.
- W2136670774 hasConceptScore W2136670774C142724271 @default.
- W2136670774 hasConceptScore W2136670774C19720800 @default.
- W2136670774 hasConceptScore W2136670774C204787440 @default.
- W2136670774 hasConceptScore W2136670774C27081682 @default.
- W2136670774 hasConceptScore W2136670774C2776002719 @default.
- W2136670774 hasConceptScore W2136670774C2776042228 @default.
- W2136670774 hasConceptScore W2136670774C2776476923 @default.
- W2136670774 hasConceptScore W2136670774C2781018748 @default.
- W2136670774 hasConceptScore W2136670774C2910070530 @default.
- W2136670774 hasConceptScore W2136670774C42219234 @default.
- W2136670774 hasConceptScore W2136670774C71924100 @default.
- W2136670774 hasConceptScore W2136670774C75603125 @default.
- W2136670774 hasConceptScore W2136670774C87813604 @default.
- W2136670774 hasIssue "12" @default.
- W2136670774 hasLocation W21366707741 @default.
- W2136670774 hasLocation W21366707742 @default.
- W2136670774 hasLocation W21366707743 @default.
- W2136670774 hasLocation W21366707744 @default.
- W2136670774 hasOpenAccess W2136670774 @default.
- W2136670774 hasPrimaryLocation W21366707741 @default.
- W2136670774 hasRelatedWork W1972944072 @default.
- W2136670774 hasRelatedWork W1985960529 @default.
- W2136670774 hasRelatedWork W2008449610 @default.
- W2136670774 hasRelatedWork W2014944530 @default.
- W2136670774 hasRelatedWork W2022386268 @default.
- W2136670774 hasRelatedWork W2031187416 @default.
- W2136670774 hasRelatedWork W2146830701 @default.
- W2136670774 hasRelatedWork W2327626612 @default.
- W2136670774 hasRelatedWork W2398429015 @default.
- W2136670774 hasRelatedWork W2405312528 @default.
- W2136670774 hasVolume "49" @default.
- W2136670774 isParatext "false" @default.
- W2136670774 isRetracted "false" @default.
- W2136670774 magId "2136670774" @default.
- W2136670774 workType "article" @default.