FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136695911> ?p ?o ?g. }

• W2136695911 endingPage "62" @default.
• W2136695911 startingPage "62" @default.
• W2136695911 abstract "Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe economic losses in the pig industry worldwide. Currently, vaccines based on inactivated PRRSV provide limited protection of pigs against infection, most likely because viral epitopes associated with the induction of neutralizing antibodies are not or poorly conserved during inactivation. To analyze the effect of inactivation procedures on the interaction of PRRSV with receptors involved in virus entry, a new assay was set up in this study. Viral entry-associated domains are most likely important for the induction of neutralizing antibodies, since neutralizing antibodies block interaction of PRRSV with cellular receptors. To investigate the interaction of PRRSV with the cellular receptors upon different inactivation procedures, attachment to and internalization of inactivated PRRSV into macrophages were monitored. AT-2 could not inactivate PRRSV completely and is therefore not useful for vaccine development. PRRSV inactivated with ultraviolet light, binary ethyleneimine and gamma irradiation, which all mainly have an effect at the genomic level, showed no difference compared to control live virus at all levels of virus entry, whereas PRRSV treated with formaldehyde, glutaraldehyde and pH changes, which all have a modifying effect on proteins, was not able to internalize into macrophages anymore. These results suggest that inactivation with methods with a main effect on the viral genome preserve PRRSV entry-associated domains and are useful for future development of an effective inactivated vaccine against PRRSV. Although PRRSV incubation at 37 degrees C can completely inactivate PRRSV with preservation of entry-associated domains, this method is not recommended for vaccine development, since the mechanism is yet unknown." @default.
• W2136695911 created "2016-06-24" @default.
• W2136695911 creator A5050912753 @default.
• W2136695911 creator A5052750090 @default.
• W2136695911 creator A5062878756 @default.
• W2136695911 date "2009-08-13" @default.
• W2136695911 modified "2023-10-16" @default.
• W2136695911 title "Assessing the functionality of viral entry-associated domains of porcine reproductive and respiratory syndrome virus during inactivation procedures, a potential tool to optimize inactivated vaccines" @default.
• W2136695911 cites W172886555 @default.
• W2136695911 cites W1959090591 @default.
• W2136695911 cites W1963800214 @default.
• W2136695911 cites W1975928061 @default.
• W2136695911 cites W1976011820 @default.
• W2136695911 cites W1976933945 @default.
• W2136695911 cites W1978729005 @default.
• W2136695911 cites W1984010127 @default.
• W2136695911 cites W1984642900 @default.
• W2136695911 cites W1986228598 @default.
• W2136695911 cites W1987499490 @default.
• W2136695911 cites W1991461832 @default.
• W2136695911 cites W1999632237 @default.
• W2136695911 cites W2000710670 @default.
• W2136695911 cites W2006800948 @default.
• W2136695911 cites W2011631359 @default.
• W2136695911 cites W2011644307 @default.
• W2136695911 cites W2021751941 @default.
• W2136695911 cites W2023349598 @default.
• W2136695911 cites W2029229226 @default.
• W2136695911 cites W2030558381 @default.
• W2136695911 cites W2033745025 @default.
• W2136695911 cites W2034259915 @default.
• W2136695911 cites W2040176815 @default.
• W2136695911 cites W2040491682 @default.
• W2136695911 cites W2042024461 @default.
• W2136695911 cites W2045062488 @default.
• W2136695911 cites W2046829837 @default.
• W2136695911 cites W2055254372 @default.
• W2136695911 cites W2057147307 @default.
• W2136695911 cites W2060361173 @default.
• W2136695911 cites W2063126050 @default.
• W2136695911 cites W2067139494 @default.
• W2136695911 cites W2073585688 @default.
• W2136695911 cites W2076346268 @default.
• W2136695911 cites W2086852038 @default.
• W2136695911 cites W2091041044 @default.
• W2136695911 cites W2096793204 @default.
• W2136695911 cites W2097006178 @default.
• W2136695911 cites W2097012512 @default.
• W2136695911 cites W2097074610 @default.
• W2136695911 cites W2098091403 @default.
• W2136695911 cites W2099469492 @default.
• W2136695911 cites W2117425132 @default.
• W2136695911 cites W2117759450 @default.
• W2136695911 cites W2118115302 @default.
• W2136695911 cites W2123804841 @default.
• W2136695911 cites W2125340740 @default.
• W2136695911 cites W2125817292 @default.
• W2136695911 cites W2128729063 @default.
• W2136695911 cites W2133109371 @default.
• W2136695911 cites W2149442307 @default.
• W2136695911 cites W2153300342 @default.
• W2136695911 cites W2157227966 @default.
• W2136695911 cites W2162868767 @default.
• W2136695911 cites W2164590227 @default.
• W2136695911 cites W2171012694 @default.
• W2136695911 cites W2210921238 @default.
• W2136695911 cites W4238945854 @default.
• W2136695911 doi "https://doi.org/10.1051/vetres/2009047" @default.
• W2136695911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19674538" @default.
• W2136695911 hasPublicationYear "2009" @default.
• W2136695911 type Work @default.
• W2136695911 sameAs 2136695911 @default.
• W2136695911 citedByCount "28" @default.
• W2136695911 countsByYear W21366959112012 @default.
• W2136695911 countsByYear W21366959112014 @default.
• W2136695911 countsByYear W21366959112015 @default.
• W2136695911 countsByYear W21366959112016 @default.
• W2136695911 countsByYear W21366959112017 @default.
• W2136695911 countsByYear W21366959112018 @default.
• W2136695911 countsByYear W21366959112019 @default.
• W2136695911 countsByYear W21366959112020 @default.
• W2136695911 countsByYear W21366959112021 @default.
• W2136695911 countsByYear W21366959112022 @default.
• W2136695911 countsByYear W21366959112023 @default.
• W2136695911 crossrefType "journal-article" @default.
• W2136695911 hasAuthorship W2136695911A5050912753 @default.
• W2136695911 hasAuthorship W2136695911A5052750090 @default.
• W2136695911 hasAuthorship W2136695911A5062878756 @default.
• W2136695911 hasBestOaLocation W21366959111 @default.
• W2136695911 hasConcept C140704245 @default.
• W2136695911 hasConcept C159047783 @default.
• W2136695911 hasConcept C159654299 @default.
• W2136695911 hasConcept C195616568 @default.
• W2136695911 hasConcept C203014093 @default.
• W2136695911 hasConcept C2522874641 @default.
• W2136695911 hasConcept C2776872762 @default.
• W2136695911 hasConcept C2779261636 @default.
• W2136695911 hasConcept C2779819720 @default.

• next