FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136700138> ?p ?o ?g. }

• W2136700138 endingPage "86" @default.
• W2136700138 startingPage "79" @default.
• W2136700138 abstract "Transcription of the mouse vas deferens protein (MVDP) gene, a member of the aldo-keto reductase superfamily, is stimulated by androgens via the androgen responsive element (ARE) located in the proximal promoter (−111 to −97). We investigated interaction between androgens and the protein kinase C (PKC) signalling pathway. Transcriptional regulation was determined by analysis of chloramphenicol acetyltransferase (CAT). T47D cells were transiently transfected with 5′ flanking MVDP DNA promoter sequences (−1804 to +41: −510 to +41; and −121 to +41) fused to the reporter (CAT) gene. Androgen-induced transcriptional activity can be enhanced from 6 (1.8 and 0.5 kb MVDP-CAT constructs) to 18 fold (0.16 kb MVDP-CAT construct), in a time and dose-dependent manner, by the PKC activator 12-o-tetradecanoylphorbol-13 acetate (TPA). A mutation in the proximal ARE abolished both androgen and TPA-dependent gene enhancement. TPA influenced minimally MMTV promoter in T47D cells and MVDP promoter in CV1 cells suggesting that the effects of the PKC activator are probably promoter and cell-specific. In contrast, activation of protein kinase A (PKA) via addition of dibutyryl-cAMP (db-cAMP) reduced androgen induction of the MVDP gene." @default.
• W2136700138 created "2016-06-24" @default.
• W2136700138 creator A5008021290 @default.
• W2136700138 creator A5009443048 @default.
• W2136700138 creator A5042633967 @default.
• W2136700138 creator A5055334835 @default.
• W2136700138 date "1996-11-01" @default.
• W2136700138 modified "2023-09-27" @default.
• W2136700138 title "Protein kinase C pathway potentiates androgen-mediated gene expression of the mouse was deferens specific aldose reductase-like protein (MVDP)" @default.
• W2136700138 cites W1484893220 @default.
• W2136700138 cites W1503898156 @default.
• W2136700138 cites W1524361670 @default.
• W2136700138 cites W1536486871 @default.
• W2136700138 cites W1578094132 @default.
• W2136700138 cites W1589290883 @default.
• W2136700138 cites W1608887613 @default.
• W2136700138 cites W168773424 @default.
• W2136700138 cites W1954929088 @default.
• W2136700138 cites W1980722886 @default.
• W2136700138 cites W1989647785 @default.
• W2136700138 cites W2001034975 @default.
• W2136700138 cites W200355757 @default.
• W2136700138 cites W2008688007 @default.
• W2136700138 cites W2043672573 @default.
• W2136700138 cites W2048242346 @default.
• W2136700138 cites W2060639696 @default.
• W2136700138 cites W2061407410 @default.
• W2136700138 cites W2065706024 @default.
• W2136700138 cites W2087116786 @default.
• W2136700138 cites W2092977977 @default.
• W2136700138 cites W2095416319 @default.
• W2136700138 cites W2119786102 @default.
• W2136700138 cites W2121625670 @default.
• W2136700138 cites W2153997727 @default.
• W2136700138 cites W224890781 @default.
• W2136700138 cites W2280018781 @default.
• W2136700138 cites W26691815 @default.
• W2136700138 cites W4230562868 @default.
• W2136700138 cites W4239267948 @default.
• W2136700138 cites W4241605571 @default.
• W2136700138 cites W4242032496 @default.
• W2136700138 cites W4243927559 @default.
• W2136700138 cites W4250099741 @default.
• W2136700138 doi "https://doi.org/10.1016/s0303-7207(96)03931-7" @default.
• W2136700138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9027327" @default.
• W2136700138 hasPublicationYear "1996" @default.
• W2136700138 type Work @default.
• W2136700138 sameAs 2136700138 @default.
• W2136700138 citedByCount "11" @default.
• W2136700138 crossrefType "journal-article" @default.
• W2136700138 hasAuthorship W2136700138A5008021290 @default.
• W2136700138 hasAuthorship W2136700138A5009443048 @default.
• W2136700138 hasAuthorship W2136700138A5042633967 @default.
• W2136700138 hasAuthorship W2136700138A5055334835 @default.
• W2136700138 hasConcept C104317684 @default.
• W2136700138 hasConcept C119157956 @default.
• W2136700138 hasConcept C134018914 @default.
• W2136700138 hasConcept C150194340 @default.
• W2136700138 hasConcept C153911025 @default.
• W2136700138 hasConcept C161733203 @default.
• W2136700138 hasConcept C184235292 @default.
• W2136700138 hasConcept C195794163 @default.
• W2136700138 hasConcept C2777911890 @default.
• W2136700138 hasConcept C2779649592 @default.
• W2136700138 hasConcept C2780730277 @default.
• W2136700138 hasConcept C54009773 @default.
• W2136700138 hasConcept C55493867 @default.
• W2136700138 hasConcept C71315377 @default.
• W2136700138 hasConcept C86803240 @default.
• W2136700138 hasConcept C88045685 @default.
• W2136700138 hasConcept C95444343 @default.
• W2136700138 hasConcept C97029542 @default.
• W2136700138 hasConceptScore W2136700138C104317684 @default.
• W2136700138 hasConceptScore W2136700138C119157956 @default.
• W2136700138 hasConceptScore W2136700138C134018914 @default.
• W2136700138 hasConceptScore W2136700138C150194340 @default.
• W2136700138 hasConceptScore W2136700138C153911025 @default.
• W2136700138 hasConceptScore W2136700138C161733203 @default.
• W2136700138 hasConceptScore W2136700138C184235292 @default.
• W2136700138 hasConceptScore W2136700138C195794163 @default.
• W2136700138 hasConceptScore W2136700138C2777911890 @default.
• W2136700138 hasConceptScore W2136700138C2779649592 @default.
• W2136700138 hasConceptScore W2136700138C2780730277 @default.
• W2136700138 hasConceptScore W2136700138C54009773 @default.
• W2136700138 hasConceptScore W2136700138C55493867 @default.
• W2136700138 hasConceptScore W2136700138C71315377 @default.
• W2136700138 hasConceptScore W2136700138C86803240 @default.
• W2136700138 hasConceptScore W2136700138C88045685 @default.
• W2136700138 hasConceptScore W2136700138C95444343 @default.
• W2136700138 hasConceptScore W2136700138C97029542 @default.
• W2136700138 hasIssue "1-2" @default.
• W2136700138 hasLocation W21367001381 @default.
• W2136700138 hasLocation W21367001382 @default.
• W2136700138 hasLocation W21367001383 @default.
• W2136700138 hasOpenAccess W2136700138 @default.
• W2136700138 hasPrimaryLocation W21367001381 @default.
• W2136700138 hasRelatedWork W1972601054 @default.
• W2136700138 hasRelatedWork W2029733737 @default.

• next