FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136711150> ?p ?o ?g. }

• W2136711150 endingPage "e100739" @default.
• W2136711150 startingPage "e100739" @default.
• W2136711150 abstract "Bacterial conjugation in the human gut microbiota is believed to play a major role in the dissemination of antibiotic resistance genes and virulence plasmids. However, the modulation of bacterial conjugation by the human host remains poorly understood and there is a need for controlled systems to study this process. We established an in vitro co-culture system to study the interaction between human intestinal cells and bacteria. We show that the conjugation efficiency of a plasmid encoding an extended spectrum beta-lactamase is reduced when clinical isolates of Escherichia coli are co-cultured with human intestinal cells. We show that filtered media from co-cultures contain a factor that reduces conjugation efficiency. Protease treatment of the filtered media eliminates this inhibition of conjugation. This data suggests that a peptide or protein based factor is secreted on the apical side of the intestinal cells exposed to bacteria leading to a two-fold reduction in conjugation efficiency. These results show that human gut epithelial cells can modulate bacterial conjugation and may have relevance to gene exchange in the gut." @default.
• W2136711150 created "2016-06-24" @default.
• W2136711150 creator A5065499506 @default.
• W2136711150 creator A5077988966 @default.
• W2136711150 date "2014-06-23" @default.
• W2136711150 modified "2023-09-25" @default.
• W2136711150 title "Human Intestinal Cells Modulate Conjugational Transfer of Multidrug Resistance Plasmids between Clinical Escherichia coli Isolates" @default.
• W2136711150 cites W1489169741 @default.
• W2136711150 cites W1585296769 @default.
• W2136711150 cites W1898485134 @default.
• W2136711150 cites W1928953700 @default.
• W2136711150 cites W1929818717 @default.
• W2136711150 cites W1936412048 @default.
• W2136711150 cites W1985600858 @default.
• W2136711150 cites W1995359262 @default.
• W2136711150 cites W1999699598 @default.
• W2136711150 cites W2003099302 @default.
• W2136711150 cites W2019140873 @default.
• W2136711150 cites W2024299566 @default.
• W2136711150 cites W2033002674 @default.
• W2136711150 cites W2034082915 @default.
• W2136711150 cites W2040274713 @default.
• W2136711150 cites W2042894986 @default.
• W2136711150 cites W2048093113 @default.
• W2136711150 cites W2051704857 @default.
• W2136711150 cites W2058710717 @default.
• W2136711150 cites W2062399100 @default.
• W2136711150 cites W2082394803 @default.
• W2136711150 cites W2084120324 @default.
• W2136711150 cites W2087984378 @default.
• W2136711150 cites W2090925778 @default.
• W2136711150 cites W2095040140 @default.
• W2136711150 cites W2099063549 @default.
• W2136711150 cites W2102001744 @default.
• W2136711150 cites W2103028444 @default.
• W2136711150 cites W2103420607 @default.
• W2136711150 cites W2112874908 @default.
• W2136711150 cites W2113528899 @default.
• W2136711150 cites W2118001436 @default.
• W2136711150 cites W2128820093 @default.
• W2136711150 cites W2128857881 @default.
• W2136711150 cites W2147692019 @default.
• W2136711150 cites W2150946253 @default.
• W2136711150 cites W2151814510 @default.
• W2136711150 cites W2153905079 @default.
• W2136711150 cites W2167591869 @default.
• W2136711150 cites W2171081455 @default.
• W2136711150 cites W4248074423 @default.
• W2136711150 doi "https://doi.org/10.1371/journal.pone.0100739" @default.
• W2136711150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067368" @default.
• W2136711150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24955767" @default.
• W2136711150 hasPublicationYear "2014" @default.
• W2136711150 type Work @default.
• W2136711150 sameAs 2136711150 @default.
• W2136711150 citedByCount "23" @default.
• W2136711150 countsByYear W21367111502015 @default.
• W2136711150 countsByYear W21367111502016 @default.
• W2136711150 countsByYear W21367111502017 @default.
• W2136711150 countsByYear W21367111502018 @default.
• W2136711150 countsByYear W21367111502019 @default.
• W2136711150 countsByYear W21367111502020 @default.
• W2136711150 countsByYear W21367111502021 @default.
• W2136711150 countsByYear W21367111502022 @default.
• W2136711150 crossrefType "journal-article" @default.
• W2136711150 hasAuthorship W2136711150A5065499506 @default.
• W2136711150 hasAuthorship W2136711150A5077988966 @default.
• W2136711150 hasBestOaLocation W21367111501 @default.
• W2136711150 hasConcept C103244968 @default.
• W2136711150 hasConcept C104317684 @default.
• W2136711150 hasConcept C133936738 @default.
• W2136711150 hasConcept C180223184 @default.
• W2136711150 hasConcept C193176779 @default.
• W2136711150 hasConcept C202751555 @default.
• W2136711150 hasConcept C22744801 @default.
• W2136711150 hasConcept C2778546792 @default.
• W2136711150 hasConcept C2778910516 @default.
• W2136711150 hasConcept C2781090273 @default.
• W2136711150 hasConcept C501593827 @default.
• W2136711150 hasConcept C523546767 @default.
• W2136711150 hasConcept C54355233 @default.
• W2136711150 hasConcept C547475151 @default.
• W2136711150 hasConcept C55493867 @default.
• W2136711150 hasConcept C60987743 @default.
• W2136711150 hasConcept C86803240 @default.
• W2136711150 hasConcept C89423630 @default.
• W2136711150 hasConceptScore W2136711150C103244968 @default.
• W2136711150 hasConceptScore W2136711150C104317684 @default.
• W2136711150 hasConceptScore W2136711150C133936738 @default.
• W2136711150 hasConceptScore W2136711150C180223184 @default.
• W2136711150 hasConceptScore W2136711150C193176779 @default.
• W2136711150 hasConceptScore W2136711150C202751555 @default.
• W2136711150 hasConceptScore W2136711150C22744801 @default.
• W2136711150 hasConceptScore W2136711150C2778546792 @default.
• W2136711150 hasConceptScore W2136711150C2778910516 @default.
• W2136711150 hasConceptScore W2136711150C2781090273 @default.
• W2136711150 hasConceptScore W2136711150C501593827 @default.
• W2136711150 hasConceptScore W2136711150C523546767 @default.
• W2136711150 hasConceptScore W2136711150C54355233 @default.

• next