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- W2136728676 abstract "We study the intron–exon structures of 684 groups of orthologs from seven diverse eukaryotic genomes and provide maximum likelihood estimates for rates and numbers of intron losses and gains in these same genes for a variety of lineages. Rates of intron loss vary from ≈2 × 10 –9 to 2 × 10 –10 per year. Rates of gain vary from 6 × 10 –13 to 4 × 10 –12 per possible intron insertion site per year. There is an inverse correspondence between rates of intron loss and gain, leading to a 20-fold variation among lineages in the ratio of the rates of the two processes. The observed rates of intron gain are insufficient to explain the large number of introns estimated to have been present in the plant–animal ancestor, suggesting that introns present in early eukaryotes may have been created by a fundamentally different process than more recently gained introns." @default.
- W2136728676 created "2016-06-24" @default.
- W2136728676 creator A5045315721 @default.
- W2136728676 creator A5051655733 @default.
- W2136728676 date "2005-04-12" @default.
- W2136728676 modified "2023-09-23" @default.
- W2136728676 title "Rates of intron loss and gain: Implications for early eukaryotic evolution" @default.
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- W2136728676 doi "https://doi.org/10.1073/pnas.0500383102" @default.
- W2136728676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/556292" @default.
- W2136728676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15827119" @default.
- W2136728676 hasPublicationYear "2005" @default.
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