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• W2136732264 endingPage "13313" @default.
• W2136732264 startingPage "13304" @default.
• W2136732264 abstract "Abstract We prepared reversed dye clusters by hybridizing two RNA oligomers, each of which tethered dyes (Methyl Red, 4′‐methylthioazobenzene, and thiazole orange) on D ‐threoninols (threoninol nucleotides) at the center of their strands. NMR spectroscopic analyses revealed that two dyes from each strand were axially stacked in an antiparallel manner to each other in the duplex, and were located adjacent to the 3′‐side of a natural nucleobase. Interestingly, this positional relationship of the dyes was completely the opposite of that assembled in DNA that we reported previously: dyes in DNA were located adjacent to the 5′‐side of a natural nucleobase. This observation was also consistent with the circular dichroism of dimerized dyes in which the Cotton effect of the dyes (i.e., the winding properties of two dyes) was inverted in RNA relative to that in DNA. Further spectroscopic analyses revealed that clustering of the dyes on RNA duplexes induced distinct hypsochromicity and narrowing of the band, thus demonstrating that the dyes were axially stacked (i.e., H‐aggregates) even on an A‐type helix. On the basis of these results, we also prepared heterodimers of a fluorophore (thiazole orange) and quencher (Methyl Red) in an RNA duplex. Fluorescence from thiazole orange was found to be strongly quenched by Methyl Red due to the excitonic interaction, so that the ratio of fluorescent intensities of the RNA–thiazole orange conjugate with and without its complementary strand carrying a quencher became as high as 27. We believe that these RNA–dye conjugates are potentially useful probes for real‐time monitoring of RNA interference (RNAi) mechanisms." @default.
• W2136732264 created "2016-06-24" @default.
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• W2136732264 date "2012-09-20" @default.
• W2136732264 modified "2023-10-18" @default.
• W2136732264 title "Reversed Assembly of Dyes in an RNA Duplex Compared with Those in DNA" @default.
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• W2136732264 doi "https://doi.org/10.1002/chem.201201956" @default.
• W2136732264 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22996355" @default.
• W2136732264 hasPublicationYear "2012" @default.
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