Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136735360> ?p ?o ?g. }
- W2136735360 endingPage "15" @default.
- W2136735360 startingPage "5" @default.
- W2136735360 abstract "The aim of the present study was to establish whether antidepressants (ADs) of potentially different chemical structure and mechanisms of action affected the phospholipase A2 (PLA2) activity in plasma membranes of the rat brain cortex. It was decided to evaluate the influence of imipramine (IMI), amitriptyline (AMI), fluvoxamine (FLU), mianserin (MIA) and tianeptine (TIA) on PLA2 activity after an acute and long-term (4 weeks) drug administration. To study the time-related effects of FLU on PLA2 activity, animals were treated for 1, 7, 14 and 28 days. The experiments were performed on male Wistar rats. The PLA2 activity was determined by the method of Strosznajder and Strosznajder as well as Jelsema with slight modifications. It was shown that ADs significantly changed the PLA2 activity in plasma membranes of the rat brain cortex and the effects depended on the dose, time of administration and the structure of the drug. Tricyclic ADs, both classic (IMI and AMI) as well as atypical (e.g. TIA) inhibited PLA2 activity. It seems that FLU was the only antidepressant, which induced either inhibition or activation of PLA2 depending on time of administration. It may be suggested that PLA2 appears to be a common target for drugs showing quite different mechanisms of action." @default.
- W2136735360 created "2016-06-24" @default.
- W2136735360 creator A5040420148 @default.
- W2136735360 creator A5040928604 @default.
- W2136735360 creator A5046726729 @default.
- W2136735360 creator A5068135859 @default.
- W2136735360 date "2003-07-15" @default.
- W2136735360 modified "2023-09-23" @default.
- W2136735360 title "Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex." @default.
- W2136735360 cites W1511017475 @default.
- W2136735360 cites W1527565099 @default.
- W2136735360 cites W1561126551 @default.
- W2136735360 cites W1577386719 @default.
- W2136735360 cites W1583075434 @default.
- W2136735360 cites W1775749144 @default.
- W2136735360 cites W1950744654 @default.
- W2136735360 cites W195212044 @default.
- W2136735360 cites W1970394874 @default.
- W2136735360 cites W1972729431 @default.
- W2136735360 cites W1976872805 @default.
- W2136735360 cites W1977595115 @default.
- W2136735360 cites W1979363416 @default.
- W2136735360 cites W1983160636 @default.
- W2136735360 cites W1983542898 @default.
- W2136735360 cites W1992405521 @default.
- W2136735360 cites W1993408250 @default.
- W2136735360 cites W1994821631 @default.
- W2136735360 cites W2003838450 @default.
- W2136735360 cites W2005802533 @default.
- W2136735360 cites W2009795896 @default.
- W2136735360 cites W2014591701 @default.
- W2136735360 cites W2016966416 @default.
- W2136735360 cites W2021892782 @default.
- W2136735360 cites W2022695672 @default.
- W2136735360 cites W2035532299 @default.
- W2136735360 cites W2053240823 @default.
- W2136735360 cites W2058759125 @default.
- W2136735360 cites W2059782824 @default.
- W2136735360 cites W2061014791 @default.
- W2136735360 cites W2065436327 @default.
- W2136735360 cites W2070551380 @default.
- W2136735360 cites W2072219714 @default.
- W2136735360 cites W2076112136 @default.
- W2136735360 cites W2077195006 @default.
- W2136735360 cites W2077760444 @default.
- W2136735360 cites W2080258840 @default.
- W2136735360 cites W2083003235 @default.
- W2136735360 cites W2084373177 @default.
- W2136735360 cites W2088533774 @default.
- W2136735360 cites W2095226139 @default.
- W2136735360 cites W2108694278 @default.
- W2136735360 cites W2128303012 @default.
- W2136735360 cites W2133631540 @default.
- W2136735360 cites W2138893502 @default.
- W2136735360 cites W2144297094 @default.
- W2136735360 cites W2401046212 @default.
- W2136735360 cites W2405154847 @default.
- W2136735360 cites W2417342290 @default.
- W2136735360 cites W2418626334 @default.
- W2136735360 cites W96379975 @default.
- W2136735360 cites W1998521152 @default.
- W2136735360 cites W2039089863 @default.
- W2136735360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12856820" @default.
- W2136735360 hasPublicationYear "2003" @default.
- W2136735360 type Work @default.
- W2136735360 sameAs 2136735360 @default.
- W2136735360 citedByCount "7" @default.
- W2136735360 countsByYear W21367353602016 @default.
- W2136735360 countsByYear W21367353602017 @default.
- W2136735360 crossrefType "journal-article" @default.
- W2136735360 hasAuthorship W2136735360A5040420148 @default.
- W2136735360 hasAuthorship W2136735360A5040928604 @default.
- W2136735360 hasAuthorship W2136735360A5046726729 @default.
- W2136735360 hasAuthorship W2136735360A5068135859 @default.
- W2136735360 hasConcept C126322002 @default.
- W2136735360 hasConcept C12927208 @default.
- W2136735360 hasConcept C142724271 @default.
- W2136735360 hasConcept C15744967 @default.
- W2136735360 hasConcept C169760540 @default.
- W2136735360 hasConcept C170493617 @default.
- W2136735360 hasConcept C181199279 @default.
- W2136735360 hasConcept C185592680 @default.
- W2136735360 hasConcept C202751555 @default.
- W2136735360 hasConcept C204787440 @default.
- W2136735360 hasConcept C2775864247 @default.
- W2136735360 hasConcept C2776120743 @default.
- W2136735360 hasConcept C2776134451 @default.
- W2136735360 hasConcept C2776551241 @default.
- W2136735360 hasConcept C2776903192 @default.
- W2136735360 hasConcept C2777348757 @default.
- W2136735360 hasConcept C2779145073 @default.
- W2136735360 hasConcept C2779177272 @default.
- W2136735360 hasConcept C2779910183 @default.
- W2136735360 hasConcept C2780035454 @default.
- W2136735360 hasConcept C2780216858 @default.
- W2136735360 hasConcept C2780831388 @default.
- W2136735360 hasConcept C2781081902 @default.
- W2136735360 hasConcept C2781161787 @default.