FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136746571> ?p ?o ?g. }

• W2136746571 endingPage "H1844" @default.
• W2136746571 startingPage "H1836" @default.
• W2136746571 abstract "In the heart, membrane voltage (Vm) and intracellular Ca (Cai) are bidirectionally coupled, so that ionic membrane currents regulate Cai cycling and Cai affects ionic currents regulating action potential duration (APD). Although Cai reliably and consistently tracks Vm at normal heart rates, it is possible that at very rapid rates, sarcoplasmic reticulum Cai cycling may exhibit intrinsic dynamics. Non-voltage-gated Cai release might cause local alternations in APD and refractoriness that influence wavebreak during ventricular fibrillation (VF). In this study, we tested this hypothesis by examining the extent to which Cai is associated with Vm during VF. Cai transients were mapped optically in isolated arterially perfused swine right ventricles using the fluorescent dye rhod 2 AM while intracellular membrane potential was simultaneously recorded either locally with a microelectrode (5 preparations) or globally with the voltage-sensitive dye RH-237 (5 preparations). Mutual information (MI) is a quantitative statistical measure of the extent to which knowledge of one variable (Vm) predicts the value of a second variable (Cai). MI was high during pacing and ventricular tachycardia (VT; 1.13 +/- 0.21 and 1.69 +/- 0.18, respectively) but fell dramatically during VF (0.28 +/- 0.06, P < 0.001). Cai at sites 4-6 mm apart also showed decreased MI during VF (0.63 +/- 0.13) compared with pacing (1.59 +/- 0.34, P < 0.001) or VT (2.05 +/- 0.67, P < 0.001). Spatially, Cai waves usually bore no relationship to membrane depolarization waves during nonreentrant fractionated waves typical of VF, whereas they tracked each other closely during pacing and VT. The dominant frequencies of Vm and Cai signals analyzed by fast Fourier transform were similar during VT but differed significantly during VF. Cai is closely associated with Vm closely during pacing and VT but not during VF. These findings suggest that during VF, non-voltage-gated Cai release events occur and may influence wavebreak by altering Vm and APD locally." @default.
• W2136746571 created "2016-06-24" @default.
• W2136746571 creator A5005698226 @default.
• W2136746571 creator A5006823579 @default.
• W2136746571 creator A5008201921 @default.
• W2136746571 creator A5009561014 @default.
• W2136746571 creator A5016024659 @default.
• W2136746571 creator A5022045533 @default.
• W2136746571 creator A5030241912 @default.
• W2136746571 creator A5031255802 @default.
• W2136746571 creator A5032603742 @default.
• W2136746571 creator A5033787067 @default.
• W2136746571 creator A5051699207 @default.
• W2136746571 creator A5053031134 @default.
• W2136746571 creator A5057554500 @default.
• W2136746571 creator A5090573749 @default.
• W2136746571 date "2004-05-01" @default.
• W2136746571 modified "2023-10-16" @default.
• W2136746571 title "Intracellular Ca dynamics in ventricular fibrillation" @default.
• W2136746571 cites W189309776 @default.
• W2136746571 cites W1964135995 @default.
• W2136746571 cites W1966711917 @default.
• W2136746571 cites W1968990812 @default.
• W2136746571 cites W1977936482 @default.
• W2136746571 cites W1990406674 @default.
• W2136746571 cites W1999042200 @default.
• W2136746571 cites W2010364320 @default.
• W2136746571 cites W2024194513 @default.
• W2136746571 cites W2025498083 @default.
• W2136746571 cites W2031053544 @default.
• W2136746571 cites W2045925085 @default.
• W2136746571 cites W2051685732 @default.
• W2136746571 cites W2055039403 @default.
• W2136746571 cites W2057665893 @default.
• W2136746571 cites W2070307456 @default.
• W2136746571 cites W2077129671 @default.
• W2136746571 cites W2110152395 @default.
• W2136746571 cites W2112532022 @default.
• W2136746571 cites W2123443387 @default.
• W2136746571 cites W2124982224 @default.
• W2136746571 cites W2149807266 @default.
• W2136746571 cites W2151975147 @default.
• W2136746571 cites W2171148992 @default.
• W2136746571 cites W2188488984 @default.
• W2136746571 cites W4210509282 @default.
• W2136746571 doi "https://doi.org/10.1152/ajpheart.00123.2003" @default.
• W2136746571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14704235" @default.
• W2136746571 hasPublicationYear "2004" @default.
• W2136746571 type Work @default.
• W2136746571 sameAs 2136746571 @default.
• W2136746571 citedByCount "84" @default.
• W2136746571 countsByYear W21367465712012 @default.
• W2136746571 countsByYear W21367465712013 @default.
• W2136746571 countsByYear W21367465712014 @default.
• W2136746571 countsByYear W21367465712015 @default.
• W2136746571 countsByYear W21367465712016 @default.
• W2136746571 countsByYear W21367465712018 @default.
• W2136746571 countsByYear W21367465712019 @default.
• W2136746571 countsByYear W21367465712020 @default.
• W2136746571 countsByYear W21367465712021 @default.
• W2136746571 countsByYear W21367465712022 @default.
• W2136746571 countsByYear W21367465712023 @default.
• W2136746571 crossrefType "journal-article" @default.
• W2136746571 hasAuthorship W2136746571A5005698226 @default.
• W2136746571 hasAuthorship W2136746571A5006823579 @default.
• W2136746571 hasAuthorship W2136746571A5008201921 @default.
• W2136746571 hasAuthorship W2136746571A5009561014 @default.
• W2136746571 hasAuthorship W2136746571A5016024659 @default.
• W2136746571 hasAuthorship W2136746571A5022045533 @default.
• W2136746571 hasAuthorship W2136746571A5030241912 @default.
• W2136746571 hasAuthorship W2136746571A5031255802 @default.
• W2136746571 hasAuthorship W2136746571A5032603742 @default.
• W2136746571 hasAuthorship W2136746571A5033787067 @default.
• W2136746571 hasAuthorship W2136746571A5051699207 @default.
• W2136746571 hasAuthorship W2136746571A5053031134 @default.
• W2136746571 hasAuthorship W2136746571A5057554500 @default.
• W2136746571 hasAuthorship W2136746571A5090573749 @default.
• W2136746571 hasConcept C12554922 @default.
• W2136746571 hasConcept C126322002 @default.
• W2136746571 hasConcept C164705383 @default.
• W2136746571 hasConcept C181911157 @default.
• W2136746571 hasConcept C185263204 @default.
• W2136746571 hasConcept C185592680 @default.
• W2136746571 hasConcept C204188946 @default.
• W2136746571 hasConcept C2776331378 @default.
• W2136746571 hasConcept C2777356233 @default.
• W2136746571 hasConcept C2779161974 @default.
• W2136746571 hasConcept C2781005686 @default.
• W2136746571 hasConcept C28289500 @default.
• W2136746571 hasConcept C4141045 @default.
• W2136746571 hasConcept C55493867 @default.
• W2136746571 hasConcept C70616116 @default.
• W2136746571 hasConcept C71924100 @default.
• W2136746571 hasConcept C79879829 @default.
• W2136746571 hasConcept C86803240 @default.
• W2136746571 hasConceptScore W2136746571C12554922 @default.
• W2136746571 hasConceptScore W2136746571C126322002 @default.
• W2136746571 hasConceptScore W2136746571C164705383 @default.

• next