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• W2136769723 abstract "10 1. REVIEW OF THE LITERATURE 11 1.1 RET RECEPTOR TYROSINE KINASE 11 1.1.1 RET gene and RET proteins 11 1.1.2 RET is a functional receptor for GDNF-family ligands (GFLs).... 12 1.1.3 RET-dependent GFLs signaling 14 1.1.4 RET-independent GDNF/GFRα1 signaling 17 1.1.5 Activation of RET by other growth factors 18 1.1.6 Role of RET signaling during development 19 1.2 RET INTERACTINGPROTEINS 20 1.2.1 Downstream signalling pathways 22 1.2.2 Shc family adaptor proteins 23 1.3 RET ACTIVATION IN HUMAN CANCER 25 1.3.1 RET in papilary carcinomas of the thyroid gland 25 1.3.2 Other genes activated in papilary thyroid carcinomas (PTCs)..... 30 1.3.3 Medulary thyroid carcinoma 30 1.3.4 RET in MEN 2 syndromes 31 1.3.5 RET in sporadic medulary thyroid carcinoma (sMTC) 36 1.3.6 Diagnosis and management of MEN 2 38 1.4 RET GERMLINE INACTIVATING MUTATIONS IN HIRSCHSPRUNG’S DISEASE 40 2. AIMS OF THE PRESENT STUDY 45 3. MATERIALS AND METHODS 46 3.1 Cel lines 46 3.2 Antibodies,growth factors,recombinant proteins,chemical inhibitors.. 46 3.3 DNA constructs 47 3.4 Transfection of cel lines 48 3.5 Adenovirus construction 49 3.6 Immunoprecipitations 49 3.7 GST proteins 50 3.8 Western bloting 50 3.9 In vitro kinase assays 50 3.10 Biotinylation of cel surface proteins 50 3.11 I-labeled GDNF and HGF binding, chemical cross-linking........ 50 3.12 Cel migration and chemotaxis assays 51 3.13 Branching tubule formation assay in colagen gel 51 3.14 Cel apoptosis assays 51 3.15 Cel proliferation assays 51 3.16 Anchorage-independent growth assay 51 3.17 Kidney cultures 51" @default.
• W2136769723 created "2016-06-24" @default.
• W2136769723 creator A5078438601 @default.
• W2136769723 date "2005-01-01" @default.
• W2136769723 modified "2023-09-24" @default.
• W2136769723 title "MOLECULAR CHARACTERISATION OF RET TYROSINE KINASE SIGNALLING" @default.
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