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• W2136808889 abstract "Cancer cells exhibit surprisingly uniform metabolic abnormalities, termed the cancer metabolic phenotype. We define six classes of mechanism giving rise to this phenotype: mechanisms associated with (1) oncogenesis; (2) rapid reproduction; (3) stress responses; (4) invasiveness and metastasis; (5) resistance to host immune surveillance; (6) resistance to therapy. Classes 1 and 2 are constitutive mechanisms, involved in the process of oncogenesis, whereas classes 4–6 mainly involve selection for features responsive to the tumor’s environment. We next analyze some well-known features of the tumor metabolic phenotype: the Warburg effect, aerobic glycolysis, and tumor pH. Contrary to accepted wisdom, tumors do not rely on glycolysis for their energy needs and their intracellular pH is not acidic.The concept of the metabolome—the totality of small-molecule metabolites in a cell—has had little attention in cancer. We discuss ways in which the cancer metabolome could be investigated, by metabolic profiling, illustrated by studies on the HIF-1 pathway. Finally, we consider ways in which tumor metabolic profiling could be used in drug discovery programs: to help chose targets from functional genomic data, to refine results from conventional screens or to provide end points for focused screens and medicinal chemistry, to predict cellular and whole-organism toxicity, and to help elucidate drug mechanisms." @default.
• W2136808889 created "2016-06-24" @default.
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• W2136808889 date "2007-12-02" @default.
• W2136808889 modified "2023-09-27" @default.
• W2136808889 title "Cancer Metabolic Phenotype" @default.
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• W2136808889 doi "https://doi.org/10.1385/1-59259-893-5:135" @default.
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