FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136822969> ?p ?o ?g. }

• W2136822969 endingPage "145" @default.
• W2136822969 startingPage "136" @default.
• W2136822969 abstract "Diazepam (DZ), the preferred anticonvulsant benzodiazepine (BZ) for the treatment of organophosphate (OP) nerve agent-induced seizures and neuronal damage, has been associated with unwanted effects such as sedation, amnesia, cardiorespiratory depression, anticonvulsant tolerance, and dependence liability. In a search for safer and more effective anticonvulsant BZs against OP-induced seizure and neuronal damage, we have previously shown that imidazenil (IMD), a low-intrinsic efficacy positive allosteric modulator of gamma-aminobutyric acid (GABA) action at α1-containing GABA(A) receptors, which has high intrinsic efficacy at α2-, α3-, and α5-containing GABA(A) receptors, is more potent and longer lasting than DZ pretreatment at protecting rats from diisopropyl fluorophosphate (DFP)-induced electrocorticographic (ECoG) seizures and neuronal damage. The effects of IMD were observed at doses that are devoid of sedative, amnestic, and anticonvulsant tolerance actions. In the present study, we compared the anticonvulsant and neuroprotective effects of a combination of atropine (2 mg/kg, ip) and pyridine-2-aldoxime methochloride (2-PAM, 20 mg/kg, ip) with IMD (0.5 mg/kg, ip) or midazolam (MDZ, 0.5-2 mg/kg, ip) administered after the onset of DFP (1.5 mg/kg, sc)-induced seizure activity. The severity of DFP-induced ECoG seizures was assessed by continuous radio telemetry recordings in unrestrained and freely moving rats. Furthermore, the extent of neuronal damage was evaluated using a neuron-specific nuclear protein immunolabeling and fluoro-jade B staining procedure. We report here that IMD is more efficacious and longer lasting than sedating doses of MDZ in protecting rats from DFP-induced ECoG seizures and neuronal damage." @default.
• W2136822969 created "2016-06-24" @default.
• W2136822969 creator A5048825104 @default.
• W2136822969 creator A5051515082 @default.
• W2136822969 creator A5052344963 @default.
• W2136822969 creator A5053936847 @default.
• W2136822969 creator A5090826335 @default.
• W2136822969 date "2010-11-22" @default.
• W2136822969 modified "2023-10-12" @default.
• W2136822969 title "Acute Imidazenil Treatment after the Onset of DFP-Induced Seizure Is More Effective and Longer Lasting than Midazolam at Preventing Seizure Activity and Brain Neuropathology" @default.
• W2136822969 cites W173911385 @default.
• W2136822969 cites W1937698500 @default.
• W2136822969 cites W1968377740 @default.
• W2136822969 cites W1971336985 @default.
• W2136822969 cites W1974915391 @default.
• W2136822969 cites W1977749822 @default.
• W2136822969 cites W1980372823 @default.
• W2136822969 cites W1980704804 @default.
• W2136822969 cites W1987980841 @default.
• W2136822969 cites W1991406095 @default.
• W2136822969 cites W1992916966 @default.
• W2136822969 cites W1993417271 @default.
• W2136822969 cites W1994983634 @default.
• W2136822969 cites W2003637083 @default.
• W2136822969 cites W2011668146 @default.
• W2136822969 cites W2013643015 @default.
• W2136822969 cites W2014699632 @default.
• W2136822969 cites W2016076282 @default.
• W2136822969 cites W2022750541 @default.
• W2136822969 cites W2036087996 @default.
• W2136822969 cites W2044250818 @default.
• W2136822969 cites W2045385574 @default.
• W2136822969 cites W2048008861 @default.
• W2136822969 cites W2051099974 @default.
• W2136822969 cites W2051841492 @default.
• W2136822969 cites W2061328912 @default.
• W2136822969 cites W2066904101 @default.
• W2136822969 cites W2072551779 @default.
• W2136822969 cites W2077051836 @default.
• W2136822969 cites W2079257658 @default.
• W2136822969 cites W2090500902 @default.
• W2136822969 cites W2092549191 @default.
• W2136822969 cites W2103180169 @default.
• W2136822969 cites W2107796771 @default.
• W2136822969 cites W2127547519 @default.
• W2136822969 cites W2138152051 @default.
• W2136822969 cites W2138302361 @default.
• W2136822969 cites W2155420406 @default.
• W2136822969 cites W2157958149 @default.
• W2136822969 cites W2169533599 @default.
• W2136822969 cites W2316190892 @default.
• W2136822969 cites W2345103702 @default.
• W2136822969 cites W4232706823 @default.
• W2136822969 cites W4234245894 @default.
• W2136822969 doi "https://doi.org/10.1093/toxsci/kfq356" @default.
• W2136822969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21097996" @default.
• W2136822969 hasPublicationYear "2010" @default.
• W2136822969 type Work @default.
• W2136822969 sameAs 2136822969 @default.
• W2136822969 citedByCount "21" @default.
• W2136822969 countsByYear W21368229692012 @default.
• W2136822969 countsByYear W21368229692013 @default.
• W2136822969 countsByYear W21368229692015 @default.
• W2136822969 countsByYear W21368229692016 @default.
• W2136822969 countsByYear W21368229692017 @default.
• W2136822969 countsByYear W21368229692018 @default.
• W2136822969 countsByYear W21368229692019 @default.
• W2136822969 countsByYear W21368229692020 @default.
• W2136822969 countsByYear W21368229692021 @default.
• W2136822969 countsByYear W21368229692022 @default.
• W2136822969 countsByYear W21368229692023 @default.
• W2136822969 crossrefType "journal-article" @default.
• W2136822969 hasAuthorship W2136822969A5048825104 @default.
• W2136822969 hasAuthorship W2136822969A5051515082 @default.
• W2136822969 hasAuthorship W2136822969A5052344963 @default.
• W2136822969 hasAuthorship W2136822969A5053936847 @default.
• W2136822969 hasAuthorship W2136822969A5090826335 @default.
• W2136822969 hasBestOaLocation W21368229691 @default.
• W2136822969 hasConcept C126322002 @default.
• W2136822969 hasConcept C15744967 @default.
• W2136822969 hasConcept C168258287 @default.
• W2136822969 hasConcept C169760540 @default.
• W2136822969 hasConcept C170493617 @default.
• W2136822969 hasConcept C25498285 @default.
• W2136822969 hasConcept C2775858608 @default.
• W2136822969 hasConcept C2776175493 @default.
• W2136822969 hasConcept C2776814716 @default.
• W2136822969 hasConcept C2777010014 @default.
• W2136822969 hasConcept C2777341932 @default.
• W2136822969 hasConcept C2777907850 @default.
• W2136822969 hasConcept C2778000748 @default.
• W2136822969 hasConcept C2778173252 @default.
• W2136822969 hasConcept C2778186239 @default.
• W2136822969 hasConcept C2778460930 @default.
• W2136822969 hasConcept C42219234 @default.
• W2136822969 hasConcept C71924100 @default.
• W2136822969 hasConcept C98274493 @default.
• W2136822969 hasConceptScore W2136822969C126322002 @default.

• next