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• W2136824765 abstract "Ligands for identifying protein aggregates are of great interest as such deposits are the pathological hallmark of a wide range of severe diseases including Alzheimer's and Parkinson's disease. Here we report the synthesis of an azide functionalized fluorescent pentameric oligothiophene that can be utilized as a ligand for multimodal detection of disease-associated protein aggregates. The azide functionalization allows for attachment of the ligand to a surface by conventional click chemistry without disturbing selective interaction with protein aggregates and the oligothiophene-aggregate interaction can be detected by fluorescence or surface plasmon resonance. In addition, a methodology where the oligothiophene ligand is employed as a capturing molecule selective for aggregated proteins in combination with an antibody detecting a distinct peptide/protein is also presented. We foresee that this methodology will offer the possibility to create a variety of multiplex sensing systems for sensitive and selective detection of protein aggregates, the pathological hallmarks of several neurodegenerative diseases." @default.
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• W2136824765 date "2015-01-01" @default.
• W2136824765 modified "2023-10-13" @default.
• W2136824765 title "An azide functionalized oligothiophene ligand – A versatile tool for multimodal detection of disease associated protein aggregates" @default.
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• W2136824765 doi "https://doi.org/10.1016/j.bios.2014.07.042" @default.
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