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- W2136828611 abstract "Ultrasound-mediated microbubbles destruction has been proposed as an innovative method for noninvasive delivering of drugs and genes to different tissues. Microbubbles are used to carry a drug or gene until a specific area of interest is reached, and then ultrasound is used to burst the microbubbles, causing site-specific delivery of the bioactive materials. Furthermore, the ability of albumin-coated microbubbles to adhere to vascular regions with glycocalix damage or endothelial dysfunction is another possible mechanism to deliver drugs even in the absence of ultrasound. This review focuses on the characteristics of microbubbles that give them therapeutic properties and some important aspects of ultrasound parameters that are known to influence microbubble-mediated drug delivery. In addition, current studies involving this novel therapeutical application of microbubbles will be discussed." @default.
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- W2136828611 date "2004-11-16" @default.
- W2136828611 modified "2023-10-01" @default.
- W2136828611 title "The use of microbubbles to target drug delivery" @default.
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- W2136828611 doi "https://doi.org/10.1186/1476-7120-2-23" @default.
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