FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136828906> ?p ?o ?g. }

• W2136828906 endingPage "338" @default.
• W2136828906 startingPage "332" @default.
• W2136828906 abstract "GAD65 is one of the major autoantigens associated with insulin-dependent diabetes mellitus (IDDM). The two peptides p17 and p18 of GAD65 that share sequence similarity with coxsackie virus (amino acid sequence identity: PEVKEK) appeared to be the major determinants of GAD65 recognized preferably by T cells from new-onset IDDM patients and their first degree relatives. In contrast, in our study unrelated control subjects frequently recognized the two GAD peptides (55%, 16/29), similar to first degree relatives (41%, 12/29) and IDDM patients post-onset (68%, 15/22). However, recent-onset IDDM patients, responded less frequently (25%, 4/16) compared with IDDM patients post-onset (p < 0.03) or unrelated control subjects (borderline significant) confirming previous observations in humans and NOD mice that T-cell reactivity to GADp17/p18 at diabetes onset is decreased. Moreover, this study demonstrated a positive correlation of T-cell proliferation to GAD p17 (amino acid 247-266) and p18 (amino acid 260-279) with simultaneous responses to both peptides in 13% of all subjects tested (n = 97) (p < 0.001). T-cell proliferation to GAD p17 was higher than to p18 in recent-onset diabetic patients, first degree relatives and unrelated control subjects (p < 0.02, p < 0.004, p < 0.002, respectively). However, in post-onset IDDM patients, the two peptides were recognized equally well. Our results show that T-cell reactivity to GAD65, peptides homologous with coxsackie protein is very frequently observed, but not primarily associated with IDDM. The temporary decline of T-cell proliferation is not associated with the beta-cell destruction process, but with clinical manifestation. The positive correlation of reactivity to the two peptides in the viral motif implicates that PEVKEK is an immunogenic epitope." @default.
• W2136828906 created "2016-06-24" @default.
• W2136828906 creator A5003357168 @default.
• W2136828906 creator A5023576332 @default.
• W2136828906 creator A5038398583 @default.
• W2136828906 creator A5038424501 @default.
• W2136828906 creator A5074953985 @default.
• W2136828906 creator A5082358271 @default.
• W2136828906 date "1997-02-21" @default.
• W2136828906 modified "2023-10-05" @default.
• W2136828906 title "T-cell reactivity to GAD65 peptide sequences shared with coxsackie virus protein in recent-onset IDDM, post-onset IDDM patients and control subjects" @default.
• W2136828906 cites W1543262127 @default.
• W2136828906 cites W191750950 @default.
• W2136828906 cites W1964761844 @default.
• W2136828906 cites W1970146294 @default.
• W2136828906 cites W1985546024 @default.
• W2136828906 cites W1987101799 @default.
• W2136828906 cites W1987913280 @default.
• W2136828906 cites W1990305944 @default.
• W2136828906 cites W1993325569 @default.
• W2136828906 cites W2004256935 @default.
• W2136828906 cites W2011658568 @default.
• W2136828906 cites W2019972832 @default.
• W2136828906 cites W2021951643 @default.
• W2136828906 cites W2036185530 @default.
• W2136828906 cites W2039743782 @default.
• W2136828906 cites W2046073245 @default.
• W2136828906 cites W2056500592 @default.
• W2136828906 cites W2066685054 @default.
• W2136828906 cites W2067360524 @default.
• W2136828906 cites W2070972996 @default.
• W2136828906 cites W2071275461 @default.
• W2136828906 cites W2078826860 @default.
• W2136828906 cites W2091985164 @default.
• W2136828906 cites W2096094429 @default.
• W2136828906 cites W2104151741 @default.
• W2136828906 cites W2111625815 @default.
• W2136828906 cites W2116408074 @default.
• W2136828906 cites W2119445785 @default.
• W2136828906 cites W2119495928 @default.
• W2136828906 cites W2125283739 @default.
• W2136828906 cites W2138937703 @default.
• W2136828906 cites W2142505530 @default.
• W2136828906 cites W2145991477 @default.
• W2136828906 cites W2148245425 @default.
• W2136828906 cites W2154100983 @default.
• W2136828906 cites W2157809446 @default.
• W2136828906 cites W2326904657 @default.
• W2136828906 cites W2329872997 @default.
• W2136828906 doi "https://doi.org/10.1007/s001250050683" @default.
• W2136828906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9084973" @default.
• W2136828906 hasPublicationYear "1997" @default.
• W2136828906 type Work @default.
• W2136828906 sameAs 2136828906 @default.
• W2136828906 citedByCount "78" @default.
• W2136828906 countsByYear W21368289062012 @default.
• W2136828906 countsByYear W21368289062013 @default.
• W2136828906 countsByYear W21368289062014 @default.
• W2136828906 countsByYear W21368289062015 @default.
• W2136828906 countsByYear W21368289062016 @default.
• W2136828906 countsByYear W21368289062017 @default.
• W2136828906 countsByYear W21368289062020 @default.
• W2136828906 countsByYear W21368289062021 @default.
• W2136828906 crossrefType "journal-article" @default.
• W2136828906 hasAuthorship W2136828906A5003357168 @default.
• W2136828906 hasAuthorship W2136828906A5023576332 @default.
• W2136828906 hasAuthorship W2136828906A5038398583 @default.
• W2136828906 hasAuthorship W2136828906A5038424501 @default.
• W2136828906 hasAuthorship W2136828906A5074953985 @default.
• W2136828906 hasAuthorship W2136828906A5082358271 @default.
• W2136828906 hasBestOaLocation W21368289061 @default.
• W2136828906 hasConcept C126322002 @default.
• W2136828906 hasConcept C134018914 @default.
• W2136828906 hasConcept C203014093 @default.
• W2136828906 hasConcept C555293320 @default.
• W2136828906 hasConcept C71924100 @default.
• W2136828906 hasConcept C86803240 @default.
• W2136828906 hasConceptScore W2136828906C126322002 @default.
• W2136828906 hasConceptScore W2136828906C134018914 @default.
• W2136828906 hasConceptScore W2136828906C203014093 @default.
• W2136828906 hasConceptScore W2136828906C555293320 @default.
• W2136828906 hasConceptScore W2136828906C71924100 @default.
• W2136828906 hasConceptScore W2136828906C86803240 @default.
• W2136828906 hasIssue "3" @default.
• W2136828906 hasLocation W21368289061 @default.
• W2136828906 hasLocation W21368289062 @default.
• W2136828906 hasOpenAccess W2136828906 @default.
• W2136828906 hasPrimaryLocation W21368289061 @default.
• W2136828906 hasRelatedWork W1966504330 @default.
• W2136828906 hasRelatedWork W1966775726 @default.
• W2136828906 hasRelatedWork W1979139803 @default.
• W2136828906 hasRelatedWork W1991560548 @default.
• W2136828906 hasRelatedWork W2030889776 @default.
• W2136828906 hasRelatedWork W2037631372 @default.
• W2136828906 hasRelatedWork W2040058909 @default.
• W2136828906 hasRelatedWork W2132898409 @default.
• W2136828906 hasRelatedWork W2748952813 @default.
• W2136828906 hasRelatedWork W4249176446 @default.

• next