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• W2136829516 abstract "Calorie restriction (CR) extends life span in a wide variety of species. Previously, we showed that calorie restriction increases the replicative life span in yeast by activating Sir2, a highly conserved NAD-dependent deacetylase. Here we test whether CR activates Sir2 by increasing the NAD/NADH ratio or by regulating the level of nicotinamide, a known inhibitor of Sir2. We show that CR decreases NADH levels, and that NADH is a competitive inhibitor of Sir2. A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR." @default.
• W2136829516 created "2016-06-24" @default.
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• W2136829516 date "2004-01-01" @default.
• W2136829516 modified "2023-10-11" @default.
• W2136829516 title "Calorie restriction extends yeast life span by lowering the level of NADH" @default.
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• W2136829516 doi "https://doi.org/10.1101/gad.1164804" @default.
• W2136829516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/314267" @default.
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