Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136840198> ?p ?o ?g. }
- W2136840198 endingPage "403" @default.
- W2136840198 startingPage "398" @default.
- W2136840198 abstract "Telomere shortening is the mechanism underlying replicative aging in fibroblasts. A variety of reports now claim that inactivation of the p16(INK4a)/pRB pathway is required in addition to telomere maintenance for the immortalization of cells such as skin keratinocytes and breast epithelial cells. We here show that the premature growth arrest of these cell types can be explained by an inadequate culture environment. Providing mesenchymal/epithelial interactions by cultivating the telomerase-expressing cells on feeder layers avoids the growth arrest associated with increased p16(INK4a). These results do not support a telomere-independent mechanism of replicative aging." @default.
- W2136840198 created "2016-06-24" @default.
- W2136840198 creator A5018167935 @default.
- W2136840198 creator A5027546462 @default.
- W2136840198 creator A5042686089 @default.
- W2136840198 creator A5046175181 @default.
- W2136840198 creator A5075500933 @default.
- W2136840198 creator A5081012778 @default.
- W2136840198 creator A5082738759 @default.
- W2136840198 date "2001-02-15" @default.
- W2136840198 modified "2023-10-10" @default.
- W2136840198 title "Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions" @default.
- W2136840198 cites W140314759 @default.
- W2136840198 cites W1500627847 @default.
- W2136840198 cites W1520658182 @default.
- W2136840198 cites W1574658543 @default.
- W2136840198 cites W1632349675 @default.
- W2136840198 cites W1963735070 @default.
- W2136840198 cites W1965695542 @default.
- W2136840198 cites W1968325292 @default.
- W2136840198 cites W1971361148 @default.
- W2136840198 cites W1976741386 @default.
- W2136840198 cites W1983052307 @default.
- W2136840198 cites W1983673827 @default.
- W2136840198 cites W1986763150 @default.
- W2136840198 cites W1992430278 @default.
- W2136840198 cites W2004314923 @default.
- W2136840198 cites W2011779395 @default.
- W2136840198 cites W2016882950 @default.
- W2136840198 cites W2022507419 @default.
- W2136840198 cites W2025791374 @default.
- W2136840198 cites W2030614613 @default.
- W2136840198 cites W2033817379 @default.
- W2136840198 cites W2039442999 @default.
- W2136840198 cites W2043204829 @default.
- W2136840198 cites W2045264627 @default.
- W2136840198 cites W2072744580 @default.
- W2136840198 cites W2079413263 @default.
- W2136840198 cites W2081327669 @default.
- W2136840198 cites W2087404852 @default.
- W2136840198 cites W2090930894 @default.
- W2136840198 cites W2100550233 @default.
- W2136840198 cites W2102606444 @default.
- W2136840198 cites W2104908670 @default.
- W2136840198 cites W2108482850 @default.
- W2136840198 cites W2117331734 @default.
- W2136840198 cites W2122740168 @default.
- W2136840198 cites W2125169413 @default.
- W2136840198 cites W2167630842 @default.
- W2136840198 cites W2324248025 @default.
- W2136840198 cites W4237219965 @default.
- W2136840198 doi "https://doi.org/10.1101/gad.859201" @default.
- W2136840198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312628" @default.
- W2136840198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11230148" @default.
- W2136840198 hasPublicationYear "2001" @default.
- W2136840198 type Work @default.
- W2136840198 sameAs 2136840198 @default.
- W2136840198 citedByCount "427" @default.
- W2136840198 countsByYear W21368401982012 @default.
- W2136840198 countsByYear W21368401982013 @default.
- W2136840198 countsByYear W21368401982014 @default.
- W2136840198 countsByYear W21368401982015 @default.
- W2136840198 countsByYear W21368401982016 @default.
- W2136840198 countsByYear W21368401982017 @default.
- W2136840198 countsByYear W21368401982018 @default.
- W2136840198 countsByYear W21368401982019 @default.
- W2136840198 countsByYear W21368401982020 @default.
- W2136840198 countsByYear W21368401982021 @default.
- W2136840198 countsByYear W21368401982022 @default.
- W2136840198 countsByYear W21368401982023 @default.
- W2136840198 crossrefType "journal-article" @default.
- W2136840198 hasAuthorship W2136840198A5018167935 @default.
- W2136840198 hasAuthorship W2136840198A5027546462 @default.
- W2136840198 hasAuthorship W2136840198A5042686089 @default.
- W2136840198 hasAuthorship W2136840198A5046175181 @default.
- W2136840198 hasAuthorship W2136840198A5075500933 @default.
- W2136840198 hasAuthorship W2136840198A5081012778 @default.
- W2136840198 hasAuthorship W2136840198A5082738759 @default.
- W2136840198 hasBestOaLocation W21368401981 @default.
- W2136840198 hasConcept C104317684 @default.
- W2136840198 hasConcept C111472728 @default.
- W2136840198 hasConcept C138885662 @default.
- W2136840198 hasConcept C177336024 @default.
- W2136840198 hasConcept C2908780919 @default.
- W2136840198 hasConcept C502942594 @default.
- W2136840198 hasConcept C522857546 @default.
- W2136840198 hasConcept C54355233 @default.
- W2136840198 hasConcept C62112901 @default.
- W2136840198 hasConcept C86803240 @default.
- W2136840198 hasConcept C89611455 @default.
- W2136840198 hasConcept C94581717 @default.
- W2136840198 hasConcept C95444343 @default.
- W2136840198 hasConceptScore W2136840198C104317684 @default.
- W2136840198 hasConceptScore W2136840198C111472728 @default.
- W2136840198 hasConceptScore W2136840198C138885662 @default.
- W2136840198 hasConceptScore W2136840198C177336024 @default.
- W2136840198 hasConceptScore W2136840198C2908780919 @default.
- W2136840198 hasConceptScore W2136840198C502942594 @default.