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• W2136853910 abstract "Tumor cells, including leukemic cells, remodel their bioenergetic system in favor of aerobic glycolysis. This process is called “the Warburg effect” and offers an attractive pharmacological target to preferentially eliminate malignant cells. In addition, recent results show that metabolic changes can be linked to tumor immune evasion. Mouse models demonstrate the importance of this metabolic remodeling in leukemogenesis. Some leukemias, although treatable, remain incurable and resistance to chemotherapy produces an elevated percentage of relapse in most leukemia cases. Several groups have targeted the specific metabolism of leukemia cells in preclinical and clinical studies to improve the prognosis of these patients, i.e. using L-asparaginase to treat pediatric acute lymphocytic leukemia (ALL). Additional metabolic drugs that are currently being used to treat other diseases or tumors could also be exploited for leukemia, based on preclinical studies. Finally, we discuss the potential use of several metabolic drugs in combination therapies, including immunomodulatory drugs (IMiDs) or immune cell-based therapies, to increase their efficacy and reduce side effects in the treatment of hematological cancers. Keywords: Cancer immunosurveillance, DCA, glutamine, metformin, MHC-I, OXPHOS, warburg effect." @default.
• W2136853910 created "2016-06-24" @default.
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• W2136853910 creator A5087895317 @default.
• W2136853910 date "2014-01-31" @default.
• W2136853910 modified "2023-09-26" @default.
• W2136853910 title "Chemical Metabolic Inhibitors for the Treatment of Blood-Borne Cancers" @default.
• W2136853910 cites W1483194800 @default.
• W2136853910 cites W1483212110 @default.
• W2136853910 cites W1493511814 @default.
• W2136853910 cites W1598851434 @default.
• W2136853910 cites W1646181671 @default.
• W2136853910 cites W1665993041 @default.
• W2136853910 cites W1918238463 @default.
• W2136853910 cites W1963987860 @default.
• W2136853910 cites W1965739405 @default.
• W2136853910 cites W1967580058 @default.
• W2136853910 cites W1970400427 @default.
• W2136853910 cites W1971347970 @default.
• W2136853910 cites W1972185242 @default.
• W2136853910 cites W1973026657 @default.
• W2136853910 cites W1975538229 @default.
• W2136853910 cites W1985011732 @default.
• W2136853910 cites W1986740965 @default.
• W2136853910 cites W1986776963 @default.
• W2136853910 cites W1987695736 @default.
• W2136853910 cites W1988924112 @default.
• W2136853910 cites W1990674452 @default.
• W2136853910 cites W1992962914 @default.
• W2136853910 cites W1993799130 @default.
• W2136853910 cites W1994497322 @default.
• W2136853910 cites W1994529148 @default.
• W2136853910 cites W1997952190 @default.
• W2136853910 cites W1999042541 @default.
• W2136853910 cites W2007674386 @default.
• W2136853910 cites W2008081350 @default.
• W2136853910 cites W2008099408 @default.
• W2136853910 cites W2011957619 @default.
• W2136853910 cites W2012843756 @default.
• W2136853910 cites W2012959199 @default.
• W2136853910 cites W2013588595 @default.
• W2136853910 cites W2019683289 @default.
• W2136853910 cites W2023947368 @default.
• W2136853910 cites W2024483482 @default.
• W2136853910 cites W2024893955 @default.
• W2136853910 cites W2025487526 @default.
• W2136853910 cites W2029671140 @default.
• W2136853910 cites W2033274952 @default.
• W2136853910 cites W2036634412 @default.
• W2136853910 cites W2037177985 @default.
• W2136853910 cites W2038652783 @default.
• W2136853910 cites W2040910597 @default.
• W2136853910 cites W2043946038 @default.
• W2136853910 cites W2046972425 @default.
• W2136853910 cites W2049923433 @default.
• W2136853910 cites W2051181260 @default.
• W2136853910 cites W2052313621 @default.
• W2136853910 cites W2054549064 @default.
• W2136853910 cites W2055255976 @default.
• W2136853910 cites W2056174640 @default.
• W2136853910 cites W2061831020 @default.
• W2136853910 cites W2068116723 @default.
• W2136853910 cites W2068275410 @default.
• W2136853910 cites W2070710923 @default.
• W2136853910 cites W2070988789 @default.
• W2136853910 cites W2073300038 @default.
• W2136853910 cites W2075306556 @default.
• W2136853910 cites W2078575160 @default.
• W2136853910 cites W2078901327 @default.
• W2136853910 cites W2079158452 @default.
• W2136853910 cites W2080051364 @default.
• W2136853910 cites W2082940625 @default.
• W2136853910 cites W2083659501 @default.
• W2136853910 cites W2086870979 @default.
• W2136853910 cites W2087330696 @default.
• W2136853910 cites W2088253442 @default.
• W2136853910 cites W2089112805 @default.
• W2136853910 cites W2089658873 @default.
• W2136853910 cites W2090406819 @default.
• W2136853910 cites W2094071170 @default.
• W2136853910 cites W2096882254 @default.
• W2136853910 cites W2099803844 @default.
• W2136853910 cites W2100260504 @default.
• W2136853910 cites W2100723895 @default.
• W2136853910 cites W2101428185 @default.
• W2136853910 cites W2102650381 @default.
• W2136853910 cites W2103413154 @default.
• W2136853910 cites W2104014368 @default.
• W2136853910 cites W2111893233 @default.
• W2136853910 cites W2112347776 @default.
• W2136853910 cites W2114452590 @default.
• W2136853910 cites W2115859409 @default.
• W2136853910 cites W2115962982 @default.

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