FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136870875> ?p ?o ?g. }

• W2136870875 endingPage "1734" @default.
• W2136870875 startingPage "1724" @default.
• W2136870875 abstract "Prognosis of small cell lung carcinoma (SCLC) is particularly poor, less than 5% of patients with extensive stage being alive after two years. We hypothesized that SCLC chemotherapy could be improved by using histone deacetylase (HDAC) inhibitors based on their ability to interfere with lysine acetylation and to alter gene expression. The goal of this study was to evaluate the anticancer efficacy of a HDAC inhibitor (valproate: VPA) on SCLC cells in combination with the standard chemotherapeutic first-line regimen (cisplatin+etoposide). We show that VPA induces apoptosis of small cell lung cancer cell lines and improves efficacy of cisplatin combined with etoposide. Both mitochondrial and death receptor pathways are involved in VPA-induced apoptosis. As expected for an HDAC inhibitor, VPA hyperacetylates histone H3. The mechanism of VPA pro-apoptotic activity involves induction of p21, inhibition of Bcl-xL, cleavage of Bid and phosphorylation of Erk and H2AX. In the presence of VPA, Bax is translocated from the cytoplasm to the mitochondria and cleaved in an 18kDa isoform. Cytochrome c is released from the mitochondria into the cytosol. Transcriptomic analyses by microarray show that VPA modulates transcription of genes (Na(+)/K(+) ATPase, Bcl-xL) involved in chemoresistance to cisplatin and etoposide. Finally, the efficacy of VPA combined with cisplatin and etoposide is supported by preclinical models of SCLC cells engrafted into SCID mice. Together, these data demonstrate that VPA augments anticancer activity of cisplatin and etoposide, two components of the standard first-line chemotherapy of small cell lung cancer." @default.
• W2136870875 created "2016-06-24" @default.
• W2136870875 creator A5005953721 @default.
• W2136870875 creator A5022327873 @default.
• W2136870875 creator A5025012859 @default.
• W2136870875 creator A5025678898 @default.
• W2136870875 creator A5034397098 @default.
• W2136870875 creator A5047336283 @default.
• W2136870875 creator A5054498413 @default.
• W2136870875 creator A5073541895 @default.
• W2136870875 date "2010-06-01" @default.
• W2136870875 modified "2023-10-06" @default.
• W2136870875 title "Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy" @default.
• W2136870875 cites W1508389343 @default.
• W2136870875 cites W1851866000 @default.
• W2136870875 cites W1880554341 @default.
• W2136870875 cites W1932169383 @default.
• W2136870875 cites W1963548334 @default.
• W2136870875 cites W1965812853 @default.
• W2136870875 cites W1966081420 @default.
• W2136870875 cites W1983819128 @default.
• W2136870875 cites W1984025642 @default.
• W2136870875 cites W1990365464 @default.
• W2136870875 cites W2002574363 @default.
• W2136870875 cites W2012173926 @default.
• W2136870875 cites W2012620089 @default.
• W2136870875 cites W2029868343 @default.
• W2136870875 cites W2032603938 @default.
• W2136870875 cites W2034076446 @default.
• W2136870875 cites W2038599271 @default.
• W2136870875 cites W2051026285 @default.
• W2136870875 cites W2060184827 @default.
• W2136870875 cites W2062853648 @default.
• W2136870875 cites W2064310618 @default.
• W2136870875 cites W2072228910 @default.
• W2136870875 cites W2078079917 @default.
• W2136870875 cites W2078708200 @default.
• W2136870875 cites W2081490747 @default.
• W2136870875 cites W2090137644 @default.
• W2136870875 cites W2090809391 @default.
• W2136870875 cites W2094043001 @default.
• W2136870875 cites W2094198005 @default.
• W2136870875 cites W2098249941 @default.
• W2136870875 cites W2103665811 @default.
• W2136870875 cites W2108113897 @default.
• W2136870875 cites W2115803781 @default.
• W2136870875 cites W2117691193 @default.
• W2136870875 cites W2127267778 @default.
• W2136870875 cites W2129956213 @default.
• W2136870875 cites W2131664752 @default.
• W2136870875 cites W2136103407 @default.
• W2136870875 cites W2139184637 @default.
• W2136870875 cites W2148232503 @default.
• W2136870875 cites W2149099455 @default.
• W2136870875 cites W2149435614 @default.
• W2136870875 cites W2152041471 @default.
• W2136870875 cites W2156712995 @default.
• W2136870875 cites W2163046373 @default.
• W2136870875 cites W2165455805 @default.
• W2136870875 cites W2165522199 @default.
• W2136870875 cites W2167256217 @default.
• W2136870875 cites W2170260373 @default.
• W2136870875 cites W2171185186 @default.
• W2136870875 cites W2272287042 @default.
• W2136870875 cites W2913381773 @default.
• W2136870875 cites W4232719563 @default.
• W2136870875 cites W4233036449 @default.
• W2136870875 cites W4251662319 @default.
• W2136870875 doi "https://doi.org/10.1016/j.ejca.2010.03.021" @default.
• W2136870875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20451370" @default.
• W2136870875 hasPublicationYear "2010" @default.
• W2136870875 type Work @default.
• W2136870875 sameAs 2136870875 @default.
• W2136870875 citedByCount "35" @default.
• W2136870875 countsByYear W21368708752012 @default.
• W2136870875 countsByYear W21368708752013 @default.
• W2136870875 countsByYear W21368708752014 @default.
• W2136870875 countsByYear W21368708752015 @default.
• W2136870875 countsByYear W21368708752016 @default.
• W2136870875 countsByYear W21368708752017 @default.
• W2136870875 countsByYear W21368708752018 @default.
• W2136870875 countsByYear W21368708752019 @default.
• W2136870875 countsByYear W21368708752020 @default.
• W2136870875 countsByYear W21368708752021 @default.
• W2136870875 countsByYear W21368708752022 @default.
• W2136870875 crossrefType "journal-article" @default.
• W2136870875 hasAuthorship W2136870875A5005953721 @default.
• W2136870875 hasAuthorship W2136870875A5022327873 @default.
• W2136870875 hasAuthorship W2136870875A5025012859 @default.
• W2136870875 hasAuthorship W2136870875A5025678898 @default.
• W2136870875 hasAuthorship W2136870875A5034397098 @default.
• W2136870875 hasAuthorship W2136870875A5047336283 @default.
• W2136870875 hasAuthorship W2136870875A5054498413 @default.
• W2136870875 hasAuthorship W2136870875A5073541895 @default.
• W2136870875 hasConcept C104317684 @default.
• W2136870875 hasConcept C190283241 @default.
• W2136870875 hasConcept C2776202225 @default.
• W2136870875 hasConcept C2776694085 @default.

• next