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• W2136878052 abstract "BackgroundOtitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. ObjectiveTo provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas. Data Sources and Review MethodsA structured search of the current literature (since June 2007). The authors searched PubMed for published literature in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. ResultsOver the past 4 years, significant progress has been made in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. These studies brought new insights into our understanding of the molecular and biochemical mechanisms underlying the molecular pathogenesis of OM and helped identify novel therapeutic targets for OM. Conclusions and Implications for PracticeOur understanding of the molecular pathogenesis of OM has been significantly advanced, particularly in the areas of inflammation, innate immunity, mucus overproduction, mucosal hyperplasia, middle ear and inner ear interaction, genetics, genome sequencing, and animal model studies. Although these studies are still in their experimental stages, they help identify new potential therapeutic targets. Future preclinical and clinical studies will help to translate these exciting experimental research findings into clinical applications." @default.
• W2136878052 created "2016-06-24" @default.
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• W2136878052 date "2013-03-27" @default.
• W2136878052 modified "2023-09-26" @default.
• W2136878052 title "Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models" @default.
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• W2136878052 doi "https://doi.org/10.1177/0194599813479772" @default.
• W2136878052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4006668" @default.
• W2136878052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23536532" @default.
• W2136878052 hasPublicationYear "2013" @default.
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