FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136908268> ?p ?o ?g. }

• W2136908268 endingPage "e108228" @default.
• W2136908268 startingPage "e108228" @default.
• W2136908268 abstract "Most meningiomas are benign, but some clinical-aggressive tumors exhibit brain invasion and cannot be resected without significant complications. To identify molecular markers for these clinically-aggressive meningiomas, we performed microarray analyses on 24 primary cultures from 21 meningiomas and 3 arachnoid membranes. Using this approach, increased transglutaminase 2 (TGM2) expression was observed, which was subsequently validated in an independent set of 82 meningiomas by immunohistochemistry. Importantly, the TGM2 expression level was associated with increasing WHO malignancy grade as well as meningioma recurrence. Inhibition of TGM2 function by siRNA or cystamine induced meningioma cell death, which was associated with reduced AKT phosphorylation and caspase-3 activation. Collectively, these findings suggest that TGM2 expression increases as a function of malignancy grade and tumor recurrence and that inhibition of TGM2 reduces meningioma cell growth." @default.
• W2136908268 created "2016-06-24" @default.
• W2136908268 creator A5009510828 @default.
• W2136908268 creator A5011096863 @default.
• W2136908268 creator A5016256238 @default.
• W2136908268 creator A5016277352 @default.
• W2136908268 creator A5022159989 @default.
• W2136908268 creator A5030172482 @default.
• W2136908268 creator A5038594306 @default.
• W2136908268 creator A5041005288 @default.
• W2136908268 creator A5065106421 @default.
• W2136908268 creator A5084195908 @default.
• W2136908268 date "2014-09-23" @default.
• W2136908268 modified "2023-10-13" @default.
• W2136908268 title "Transglutaminase 2 Expression Is Increased as a Function of Malignancy Grade and Negatively Regulates Cell Growth in Meningioma" @default.
• W2136908268 cites W1971747778 @default.
• W2136908268 cites W1974686476 @default.
• W2136908268 cites W2001379435 @default.
• W2136908268 cites W2003198145 @default.
• W2136908268 cites W2005010556 @default.
• W2136908268 cites W2005772425 @default.
• W2136908268 cites W2007726926 @default.
• W2136908268 cites W2015288103 @default.
• W2136908268 cites W2019753243 @default.
• W2136908268 cites W2025712785 @default.
• W2136908268 cites W2027838880 @default.
• W2136908268 cites W2036291381 @default.
• W2136908268 cites W2038437697 @default.
• W2136908268 cites W2052178042 @default.
• W2136908268 cites W2058400687 @default.
• W2136908268 cites W2062809578 @default.
• W2136908268 cites W2064263380 @default.
• W2136908268 cites W2072539113 @default.
• W2136908268 cites W2080865567 @default.
• W2136908268 cites W2088795541 @default.
• W2136908268 cites W2095512379 @default.
• W2136908268 cites W2105398225 @default.
• W2136908268 cites W2110614387 @default.
• W2136908268 cites W2114025056 @default.
• W2136908268 cites W2115847623 @default.
• W2136908268 cites W2120899737 @default.
• W2136908268 cites W2131596322 @default.
• W2136908268 cites W2149506749 @default.
• W2136908268 cites W2153899562 @default.
• W2136908268 cites W2155756657 @default.
• W2136908268 cites W2161085873 @default.
• W2136908268 cites W2161976618 @default.
• W2136908268 doi "https://doi.org/10.1371/journal.pone.0108228" @default.
• W2136908268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4172767" @default.
• W2136908268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25247996" @default.
• W2136908268 hasPublicationYear "2014" @default.
• W2136908268 type Work @default.
• W2136908268 sameAs 2136908268 @default.
• W2136908268 citedByCount "11" @default.
• W2136908268 countsByYear W21369082682015 @default.
• W2136908268 countsByYear W21369082682017 @default.
• W2136908268 countsByYear W21369082682018 @default.
• W2136908268 countsByYear W21369082682019 @default.
• W2136908268 countsByYear W21369082682020 @default.
• W2136908268 countsByYear W21369082682021 @default.
• W2136908268 countsByYear W21369082682022 @default.
• W2136908268 crossrefType "journal-article" @default.
• W2136908268 hasAuthorship W2136908268A5009510828 @default.
• W2136908268 hasAuthorship W2136908268A5011096863 @default.
• W2136908268 hasAuthorship W2136908268A5016256238 @default.
• W2136908268 hasAuthorship W2136908268A5016277352 @default.
• W2136908268 hasAuthorship W2136908268A5022159989 @default.
• W2136908268 hasAuthorship W2136908268A5030172482 @default.
• W2136908268 hasAuthorship W2136908268A5038594306 @default.
• W2136908268 hasAuthorship W2136908268A5041005288 @default.
• W2136908268 hasAuthorship W2136908268A5065106421 @default.
• W2136908268 hasAuthorship W2136908268A5084195908 @default.
• W2136908268 hasBestOaLocation W21369082681 @default.
• W2136908268 hasConcept C142724271 @default.
• W2136908268 hasConcept C178498320 @default.
• W2136908268 hasConcept C181199279 @default.
• W2136908268 hasConcept C193270364 @default.
• W2136908268 hasConcept C204232928 @default.
• W2136908268 hasConcept C2779160599 @default.
• W2136908268 hasConcept C2779399171 @default.
• W2136908268 hasConcept C502942594 @default.
• W2136908268 hasConcept C54355233 @default.
• W2136908268 hasConcept C55493867 @default.
• W2136908268 hasConcept C62112901 @default.
• W2136908268 hasConcept C71924100 @default.
• W2136908268 hasConcept C86803240 @default.
• W2136908268 hasConceptScore W2136908268C142724271 @default.
• W2136908268 hasConceptScore W2136908268C178498320 @default.
• W2136908268 hasConceptScore W2136908268C181199279 @default.
• W2136908268 hasConceptScore W2136908268C193270364 @default.
• W2136908268 hasConceptScore W2136908268C204232928 @default.
• W2136908268 hasConceptScore W2136908268C2779160599 @default.
• W2136908268 hasConceptScore W2136908268C2779399171 @default.
• W2136908268 hasConceptScore W2136908268C502942594 @default.
• W2136908268 hasConceptScore W2136908268C54355233 @default.
• W2136908268 hasConceptScore W2136908268C55493867 @default.
• W2136908268 hasConceptScore W2136908268C62112901 @default.
• W2136908268 hasConceptScore W2136908268C71924100 @default.

• next